Olprez Tablet 20 Milligrams (Olmesartan Medoxomil)

Adult dose

The recommended initial dose is 10mg once daily, administered regardless of meals. If blood pressure is not adequately controlled at this dose, it may be increased to 20mg once daily. If further blood pressure reduction is required, it may be increased up to a maximum of 40mg once daily. The antihypertensive effect will appear within two weeks of treatment initiation, with peak effects observed after about 8 weeks. If blood pressure is not adequately controlled with this medication alone, it may be administered with thiazide diuretics such as hydrochlorothiazide. To enhance compliance, it is recommended to take it at the same time each day (e.g., in the morning). For patients at risk of intravascular volume depletion (e.g., patients on diuretics, particularly those with renal impairment), treatment should be initiated at a lower dose while closely monitoring their condition.

Child dose

The safety and efficacy for pediatric patients have not been established.

This medication can cause serious harm or death to the fetus and newborn if administered to pregnant women in the second or third trimester, so it should be discontinued immediately upon confirmation of pregnancy. It should not be used in individuals who are allergic to any of the components, who are pregnant or nursing, who are receiving kidney dialysis, have severe liver dysfunction, are patients with biliary obstruction, or have specific genetic lactose intolerance. Patients with reduced blood volume or sodium deficiency may experience hypotension, so their condition should be carefully checked prior to treatment, and appropriate medical attention should be sought immediately if any unusual symptoms occur. It should be used with caution in patients with weakened kidney function or those who have received kidney transplants, and potassium levels and kidney function should be frequently monitored. Due to the risk of hyperkalemia, patients with heart failure or renal impairment should carefully observe serum potassium levels. Special attention is required in patients with aortic stenosis, mitral valve stenosis, obstructive diseases, and hypertrophic heart disease. This medication lowers blood pressure, which may lead to dizziness; therefore, caution is needed when driving or operating hazardous machinery. Mild side effects such as dizziness, headache, abdominal pain, and cough may occur during the course of this medication, and in rare cases, angioedema or liver dysfunction may develop. If chronic diarrhea, significant weight loss, or any gastrointestinal abnormality occurs, consultation with healthcare professionals should be conducted promptly, and the medication should be discontinued if necessary. Caution is advised when using potassium-sparing diuretics or potassium supplements as blood potassium levels may increase. When taken with other antihypertensive agents, the hypotensive effect may be amplified, requiring regular blood pressure monitoring. The combination of this drug with lithium is not recommended, as it may lead to increased lithium levels and toxicity. When used in conjunction with non-steroidal anti-inflammatory drugs, renal function deterioration may occur; therefore, adequate hydration and careful monitoring of renal function are necessary. Using this drug alongside other angiotensin-related medications may increase the risks of hypotension, hyperkalemia, and kidney dysfunction, requiring close observation according to medical advice. Women breastfeeding should consider whether to discontinue nursing or the medication, as it may pass into breast milk. The safety and efficacy for pediatric patients have not been sufficiently established; hence, it should be administered cautiously to children. Elderly patients may have increased systemic drug concentration, requiring careful administration. In cases of overdose, symptoms such as hypotension or cardiac arrhythmias may manifest, necessitating appropriate treatment based on the symptoms.

Serious side effects

Urticaria, angioedema, facial edema, anaphylactic reactions, chronic malabsorption syndrome-like intestinal disease, intestinal vascular edema, hyperkalemia, acute renal failure, elevated serum creatinine, hair loss, pruritus, severe allergic reactions, liver dysfunction, autoimmune hepatitis

Mild side effects

• Dizziness
• headache
• palpitations
• hypercholesterolemia
• hyperlipidemia
• hyperuricemia
• arthralgia
• arthritis
• myalgia
• rash

This medication should be stored in a tightly sealed container to prevent air or moisture from entering. The recommended storage temperature is between 1 and 25 degrees Celsius to safely maintain the medication's effectiveness.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle