Fosfenem Injection 1 Gram (Meropenem Trihydrate)

Adult administration

Administer meropenem trihydrate at a dose of 0.5 to 1 g (as measured) daily, divided into 2 to 3 doses, administered via intravenous drip for more than 30 minutes. For suspected infections in patients with pathogenic pneumonia, peritonitis, or neutropenia, administer 1 g (as measured) via intravenous drip every 8 hours. For cystic fibrosis or meningitis, administer 2 g (as measured) via intravenous drip every 8 hours.

Child administration

For bacterial meningitis in children over 3 months, administer 40 mg per kg body weight via intravenous drip every 8 hours for at least 30 minutes, depending on the pathogen susceptibility and patient's condition and type of infection.

This drug should not be used in patients who have previously experienced shock due to this medication. Patients taking sodium valproate should use caution as using this drug may lower the blood concentration of valproate, potentially leading to a recurrence of seizures. Patients who have had allergic reactions to this drug or its constituents, as well as those who have experienced severe allergic reactions to other carbapenem or beta-lactam antibiotics, should not receive this medication. Patients with an allergic constitution, bronchial asthma, rashes, etc. should use this drug with caution, and patients with impaired renal function may require dosage adjustments due to prolonged drug retention and potential side effects. Caution should especially be exercised in patients with epilepsy, central nervous system diseases, severe liver dysfunction, the elderly, infants, and patients unable to take orally. This drug can rarely cause allergic reactions such as shock, anaphylaxis, rashes, hives, and may affect blood parameters, liver or kidney function, severe diarrhea, and neurological symptoms; if unusual symptoms occur, discontinue the medication immediately and inform medical personnel. Long-term use or use for more than 7 days should be closely monitored for liver function tests and occurrence of side effects such as rashes. This medication may interact with other drugs, so especially consult a physician when used in conjunction with probenecid, valproate, anticonvulsants, hormones, and warfarin, and verify status through blood tests. Pregnant women or those who may become pregnant should only use this medication if the benefits outweigh the risks, and breastfeeding should be avoided as this drug may be secreted in breast milk. Safety for infants under 3 months has not been established; thus, caution is needed for patients in this age group. Elderly patients have a higher risk of side effects due to decreased body function, thus dosage and administration intervals should be adjusted and their condition should be closely monitored. Prior to administration, check for a history of allergies to beta-lactam drugs, and closely observe the patient's condition during treatment and respond appropriately if unusual reactions occur. This drug is for intravenous injection only; use it as soon as it is dissolved, and if it needs to be preserved, use it within the designated time. Caution is needed during driving or operating machinery as symptoms such as headaches or mental confusion may appear, and if symptoms of muscle pain or weakness indicative of rhabdomyolysis occur, notify medical personnel immediately and discontinue use.

Serious side effects

Shock, anaphylaxis-like symptoms, severe swelling, difficulty breathing, hives, severe allergic reactions, severe skin reactions, toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme, acute generalized exanthematous pustulosis, liver failure, jaundice, fulminant hepatitis, acute renal failure, severe edema, urinary disturbances, interstitial pneumonia, pulmonary edema, respiratory distress, asthma, seizures, consciousness disturbances, convulsions, severe neurological symptoms, hypertension, heart failure, cardiac arrest

Mild side effects

• Oral discomfort
• wheezing
• dizziness
• diarrhea
• tinnitus
• sweating
• rash
• hives
• heat sensation
• erythema

Store this medication in a sealed container to prevent exposure to air or moisture, and it is best to keep it at room temperature between 1 degree and 30 degrees Celsius.

Appearance

A vial filled with crystalline powder, white to light yellow in color

Package unit

10 vials