Promact 300 mg (Valproate Magnesium)

Adult dose

Adults: Administer 800 ∼ 1,500 mg of magnesium valproate orally per day in 2 ∼ 3 divided doses.

This medication should not be administered to pregnant women except in special cases. Women who may become pregnant must use effective contraception, and if planning to become pregnant, they should consult a doctor. This medication should not be administered to patients with severe functional abnormalities of the liver and pancreas or those with a history of liver diseases. Particular caution is needed for children under 3 years of age due to a high risk of liver damage. During the use of this medication, changes in mental health, such as suicidal impulses or behaviors and depression, should be closely monitored, and if any abnormal symptoms occur, healthcare personnel should be notified immediately. Regular liver function tests must be performed, and signs of liver damage should be closely monitored, especially during the first 6 months after starting treatment. Symptoms of liver damage include loss of appetite, upper abdominal pain, vomiting, and fatigue. If acute abdominal pain, vomiting, or loss of appetite occurs, pancreatitis should be suspected, and immediate medical attention should be sought. If pancreatitis is confirmed, the administration of this medication should be discontinued. This medication may interact with other drugs, so patients must inform their doctor or pharmacist of any other medications they are taking. Special care is required as the effectiveness of this medication may decrease when used in conjunction with estrogen-containing hormonal contraceptives. Patients should avoid using alcohol or central nervous system depressants during treatment, as drowsiness or dizziness may occur, and they should refrain from driving or operating hazardous machinery. Abruptly discontinuing this medication may worsen seizures; hence, any changes in dosage or cessation should be done gradually in consultation with healthcare personnel. In case of overdose, symptoms such as coma, confusion, and muscle weakness may occur, and immediate emergency treatment is necessary. This medication should never be crushed or chewed and must be taken with water. Store out of the reach of children and preferably do not transfer to another container.

Changes in liver function test results, severe liver damage, increased seizure frequency, altered consciousness, somnolence, comatose state, cognitive impairment, symptoms of dementia, Parkinsonism, postural micro tremor, drowsiness, sedative effect, tremor, ataxia, headache, confusion, convulsions, myoclonus, hallucinations, dizziness, insomnia, anxiety, visual disturbances, nystagmus, diplopia, inability to maintain fixed posture, seeing spots in front of the eyes, speech disorders, sensory changes, excessive salivation, coma, hyperammonemia, consciousness disturbances, suicidal impulses, suicidal behaviors, depression, abnormal changes in mood and behavior, increased appetite, abnormal weight gain, abdominal pain, loss of appetite, discomfort in the stomach area, constipation, oral mucositis, nausea, gastric pain, vomiting, diarrhea, pancreatitis, irregular menstruation, secondary amenorrhea, polycystic ovary syndrome, breast enlargement, galactorrhea, hyperandrogenemia, thyroid dysfunction, hair loss, hair discoloration, curly hair, skin rash, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, muscle weakness, decreased fibrinogen, decreased coagulation factor VIII concentration, prolonged bleeding time, hyperglycinemia, anemia, macrocytosis, pancytopenia, leukopenia, thrombocytopenia, hemolytic anemia, macrocytic anemia, granulocytopenia, decreased platelet aggregation, lymphocytopenia, neutropenia, petechiae, contusions, hematoma formation, true hemorrhage, pure red cell aplasia, bone marrow failure, hearing loss, tinnitus, interstitial nephritis, nocturia, Fanconi syndrome, hyperinsulinemia, decreased IGFBP-I, hypothermia, hyponatremia, syndrome of inappropriate secretion of antidiuretic hormone, allergic reactions, angioedema, DRESS syndrome, erythema nodosum, vasculitis, brain atrophy, dementia, hematuria, polydipsia, lethargy, epistaxis, systemic edema, localized edema, weight loss, weight gain, lupus-like syndrome, confusion, sedation, coma, myasthenia gravis, diminished reflexes, areflexia, hypotension, pupillary constriction, cardiovascular diseases, respiratory diseases, cerebral edema, metabolic acidosis, hypokalemia, hypernatremia, abnormal neurological responses, behavioral changes, seizures, hypoglycemia, hypothyroidism, hematological abnormalities, withdrawal symptoms, agitation, irritability, hyperexcitability, restlessness, hyperactivity, tension-type disorders, tremors, convulsions, eating disorders

This medication is sensitive to light and should be stored in a light-protected container. Additionally, to ensure safe storage, it is important to keep the medication at room temperature, that is, between 1 to 30 degrees Celsius.

Appearance

White oval enteric-coated film-coated tablets

Package unit

30 tablets/bottle, 200 tablets/bottle