Krelorush Tablets 20mg (Rosuvastatin Calcium)

Adult dosage

It can be administered at any time of the day regardless of meals. The initial dose is 5 mg once daily, with maintenance doses adjusted according to treatment goals. The maintenance dose is typically 10 mg once daily, which is adequate for most patients. The maintenance dosage may be adjusted based on LDL cholesterol levels, treatment goals, and patients’ responses with an interval of 4 weeks or more, and the dose can be increased up to a maximum of 20 mg per day.

Children's dosage

For pediatric patients with heterozygous familial hypercholesterolemia (ages 10 to 17), a dose of 5mg to 20mg is administered once daily. The dosage can be adjusted based on treatment goals with an interval of 4 weeks or more.

This medication should not be used in certain patients. Firstly, individuals allergic to any ingredients in this drug should not take it. Patients with active liver disease or abnormally elevated liver enzyme levels should avoid this drug. Patients with muscle disease or severely impaired kidney function, and women who are pregnant or breastfeeding should not use this drug. Moreover, patients at high risk of myopathy, especially those taking high doses, should avoid this drug, and caution is needed for those with a family history of genetic muscle disorders, alcohol dependence, or hypothyroidism. This drug contains lactose and is not suitable for patients with lactose intolerance or related hereditary conditions. When administered to patients with a history of excessive alcohol consumption or liver disease, liver function tests should be performed frequently, and patients with hypothyroidism or nephrotic syndrome should treat the underlying condition first. If symptoms of muscle pain or weakness occur, immediate consultation with healthcare professionals is necessary, and blood tests may be needed to assess muscle damage. In cases of acute severe disease or onset of severe muscle weakness, the medication should be discontinued. Also, this medication may increase the risk of muscle-related side effects when taken with certain other drugs, so it is important to consult healthcare professionals about concomitant medications. Patients on high doses should undergo kidney function tests, and Asian patients may require dosage adjustments due to higher drug concentrations. This medication can be used in children and adolescents but impacts on growth and maturation should be monitored. While taking this medication, rare occurrences of liver function abnormalities, skin rash, severe muscle damage, etc., can arise, so any abnormal symptoms should be consulted with healthcare professionals immediately. Women who are pregnant or planning to become pregnant must consult healthcare professionals and use appropriate contraceptive methods. In case of overdose, there is no specific antidote available, and treatment based on symptoms along with liver function and muscle enzyme tests is necessary. Care should be taken when driving or operating machinery as dizziness may occur. Lastly, this drug has been reported to have rare side effects such as interstitial lung disease, so if shortness of breath or persistent cough occurs, immediate consultation with healthcare professionals is necessary.

Serious side effects

Allergic reactions including hives and angioedema, chest tightness, difficulty breathing, Stevens-Johnson syndrome, drug reaction with eosinophilia and systemic symptoms (DRESS), pancreatitis, jaundice, hepatitis, acute renal failure, oliguria, severe edema, severe muscle weakness, ocular myasthenia, immune-mediated necrotizing myopathy, rhabdomyolysis, severe allergic reactions, severe skin reactions, respiratory issues, liver abnormalities (jaundice

Mild side effects

• Headache
• dizziness
• constipation
• nausea
• abdominal pain
• itching
• myalgia
• weakness
• cough
• diarrhea

This medication should be kept in a tightly closed container to protect it from air and moisture and stored in a cool place at or below 30 degrees Celsius. This will help to maintain its effectiveness for a longer period.

Appearance

Pink round film-coated tablets

Package unit

30 tablets (10 tablets/alu-alu x 3)