Lestab 10 mg (Rosuvastatin Calcium)

Adult dose

For primary hypercholesterolemia and related conditions, initiate treatment with 5 mg once daily at any time regardless of meals, and if necessary, increase the dose to 10 mg once daily. Dosage adjustments should be made based on LDL cholesterol levels and patient response at intervals of at least 4 weeks, with a maximum dose of 20 mg once daily.

Child dose

For pediatric patients with heterozygous familial hypercholesterolemia (ages 10 to 17 years), the recommended dose is between 5 mg and 20 mg once daily, with dosage adjusted individually based on treatment goals at intervals of at least 4 weeks.

This medication should not be administered to certain patients. First, individuals allergic to the ingredients of this medication or with unexplained liver dysfunction should not use it. Patients with myopathy or taking certain immunosuppressants, and those with severe renal impairment should also avoid this medication. Women who are pregnant or breastfeeding, as well as women of childbearing potential, must use appropriate contraception methods and carefully weigh the risks and benefits. This medication requires special caution for individuals prone to muscle disease. Patients with mild to moderate renal impairment, hypothyroidism, family history of muscle issues, those who consume alcohol excessively, and Asian patients may require dosage adjustment. Patients with specific genetic metabolic disorders, such as lactose intolerance, should not take this medication. Patients with a history of liver disease or those who consume excessive alcohol should undergo liver function tests before starting this medication and regularly monitor liver function during treatment. Symptoms such as muscle pain, weakness, or spasms should be reported to healthcare professionals immediately, and muscle enzyme tests should be conducted if necessary. This medication can rarely cause serious skin reactions or liver damage, so if symptoms like rash, itching, or jaundice appear, use should be discontinued immediately, and consultation with a doctor is required. There may be interactions with other medications, so it is crucial to inform healthcare professionals about any current medications being taken, especially with certain antivirals, immunosuppressants, and fibrate drugs, as the risk of muscle disease may increase. It is advised not to take this medication if pregnant or breastfeeding, and women planning to become pregnant should consult with healthcare professionals and use appropriate contraception. In case of overdose, there is no specific antidote, and treatment should be carried out based on symptoms while monitoring liver function and muscle enzyme levels. Caution is required while driving or operating machinery as this medication may cause dizziness. This medication may show higher plasma concentrations in Asian individuals, so this should be considered in dosing decisions, and pediatric or adolescent patients should be carefully monitored for growth and development.

Serious side effects

• Allergic reactions including hives and angioedema, severe allergic reactions
• Pancreatitis
• Myopathy, rhabdomyolysis, immune-mediated necrotizing myopathy
• Severe muscle weakness, ophthalmoplegia
• Jaundice, hepatitis, liver abnormalities (jaundice)
• Stevens-Johnson syndrome, eosinophilia with systemic symptoms drug reaction syndrome (DRESS), severe skin reactions
• Acute renal failure, oliguria, elevated serum creatinine
• Difficulty breathing, respiratory distress

Mild side effects

• Headache
• dizziness
• constipation
• nausea
• abdominal pain
• itching
• rash
• myalgia
• weakness
• diarrhea

This medication should be stored in a tightly closed container to protect it from air and moisture, at room temperature between 1 and 30 degrees Celsius. Storing it this way will help maintain the effectiveness and prevent degradation of the medication.

Appearance

Pink round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle