Neuropehnem 500 mg (Meropenem Hydrate)

Adult administration

As Meropenem Hydrate, administer 0.5 to 1 g (activity) daily divided into 2 to 3 doses by slow intravenous infusion over more than 30 minutes. For suspected infections in patients with pathogenic pneumonia, peritonitis, and neutropenia, administer 1 g (activity) by slow intravenous infusion every 8 hours. For cystic fibrosis and meningitis, administer 2 g (activity) by slow intravenous infusion every 8 hours.

Child administration

For bacterial meningitis in children over 3 months of age, administer 40 mg per kg of body weight every 8 hours by slow intravenous infusion over more than 30 minutes, depending on the pathogen's susceptibility and the patient's condition, and type of infection. Severe

This medication should not be used in certain patients. For example, it should not be administered to patients who have experienced severe allergic reactions or shock to this drug, patients taking valproate sodium, and patients with hypersensitivity to this medication or similar antibiotics. Additionally, it should be used with caution in individuals with asthma or allergies, patients with kidney or liver issues, those with central nervous system diseases, the elderly, and infants, as they may experience more severe side effects. When using this medication, various side effects may occur, including shock, allergic reactions, blood abnormalities, liver function decline, kidney problems, gastrointestinal disturbances, central nervous system abnormalities, respiratory issues, and severe skin reactions. Symptoms should be reported to medical personnel immediately. This medication should be used only for the minimum period required to prevent resistant bacteria, and it is important to check its effectiveness through sensitivity testing before and during administration. Regular checks for liver function, kidney function, and blood tests should be conducted to detect any signs early and take appropriate action. This medication may interact with certain drugs, so it is essential to inform medical personnel of any other medications being taken, especially with valproate, antiepileptics, hormonal drugs, and anticoagulants. Women who are pregnant or may become pregnant should consider the risks and benefits cautiously before administration as it may pose a risk. If breastfeeding, it is advisable to avoid this medication as it may be excreted in breast milk. It is preferable not to use this medication in infants under 3 months old as safety and efficacy have not been established. The elderly may experience easier occurrence of side effects due to decreased bodily functions; hence, careful observation and dosage adjustments are recommended. This medication is for intravenous use only, should be used as soon as possible after reconstitution, and must be stored according to specified times and temperatures. Lastly, this medication may cause cross-reactivity with other beta-lactam antibiotics; therefore, patients with a history of allergic reactions to such drugs should consult medical personnel.

Serious side effects

Shock, anaphylaxis, urticaria, angioedema, rash, severe skin reactions (toxic epidermal necrolysis, Stevens-Johnson syndrome, DRESS syndrome, erythema multiforme, acute generalized exanthematous pustulosis), liver failure, jaundice, fulminant hepatitis, acute renal failure, pseudomembranous colitis, asthma, respiratory distress, pulmonary edema, rhabdomyolysis, headache (severe headache and thunderclap headache), seizures, altered consciousness, central nervous system symptoms, thrombophlebitis, heart failure,

Mild side effects

• Dizziness
• diarrhea
• tinnitus
• sweating
• warmth
• erythema
• itching
• fever
• redness
• general flushing

This medication should be stored in a sealed container to prevent exposure to air, preferably at room temperature between 1 degree and 30 degrees. This storage method helps maintain the drug's efficacy and prevents degradation.

Appearance

A colorless, transparent vial filled with a crystalline powder that is white to light yellow.

Package unit

10 vials