Ronasen Tablet 2 mg (Blonanserin) / Ronasen Tablet 4 mg (Blonanserin)

Adult dose

Adults: The usual dose is 4 mg per dose, twice daily after meals by oral administration; increase the dose gradually. The maintenance dose is 8~16 mg per day, divided into 2 doses after meals. As absorption of this medicine is readily affected by food, it must be taken after meals. Carefully monitor and adjust the dose for each patient so that it is the minimum required dose, and do not exceed the maximum daily dose of 24mg.

Care should be taken as this medication may increase the risk of death in elderly patients with cognitive impairment. The risk of cerebrovascular disease may increase in dementia patients, and patients at risk of stroke should exercise particular caution. The possibility of venous thromboembolism exists, so risk factors for thrombosis should be checked and preventive measures should be taken before and during the use of this medication. Patients who are in a comatose state or those taking strong central nervous system depressants, or those taking certain antifungal or antiviral medications, should not use this medication. Patients with genetic metabolic issues such as lactose intolerance should also avoid administration. Patients with cardiovascular disease, Parkinson's disease, epilepsy, those at risk of suicide, liver dysfunction, and diabetes should be administered with caution and must consult healthcare professionals immediately if any abnormal symptoms occur. This medication can cause serious side effects such as neuroleptic malignant syndrome, tardive dyskinesia, paralytic ileus, syndrome of inappropriate antidiuretic hormone secretion, rhabdomyolysis, liver dysfunction, and hyperglycemia; hence, if any abnormal symptoms occur, it should be discontinued and treated immediately. Drowsiness or reduced concentration may occur during use, so caution should be exercised when driving a car or operating dangerous machinery. When used in combination with drugs that affect liver function, blood concentration may increase; therefore, patients must inform their healthcare professionals if they are taking such medications. Women who are pregnant or breastfeeding should consult with a physician before administration, as it may affect the fetus or newborn. The safety in pediatric and neonatal populations has not been established; therefore, use is not recommended. This medication must be taken after meals, as absorption may decrease when taken on an empty stomach.

Neuroleptic Malignant Syndrome, Akinetic Mutism, Severe Muscle Rigidity, Dysphagia, Tachycardia, Blood Pressure Fluctuations, Sweating, Myoglobinuria, Renal Dysfunction, Altered Consciousness, Respiratory Distress, Circulatory Collapse, Dehydration, Acute Kidney Injury, Delayed Movement Disorders, Involuntary Muscle Movements Around the Mouth, Paralytic Ileus, Appetite Decrease, Nausea, Vomiting, Severe Diarrhea, Abdominal Distension, Lethargy, Syndrome of Inappropriate Antidiuretic Hormone Secretion, Hyponatremia, Hypotonicity, Excessive Sodium Excretion in Urine, High Volume Urine, Seizures, Rhabdomyolysis, Myalgia, Feeling Weak, Elevated CK, Elevated Myoglobin in Blood, Elevated Myoglobin in Urine, Agranulocytosis, Leukopenia, Liver Dysfunction, Elevated AST, Elevated ALT, Elevated γ-GTP, Elevated ALP, Elevated Bilirubin, Hyperglycemia, Diabetic Ketoacidosis, Diabetic Coma, Eosinophilia, Systemic Drug Reaction, Rash, Eczema, Itching, Hypotension, Orthostatic Hypotension, Elevated Blood Pressure, Electrocardiogram Abnormalities, Tachycardia, Bradycardia, Arrhythmia, Ventricular Ectopic Beats, Atrial Ectopic Beats, Palpitations, Decreased Heart Rate, Parkinson's Syndrome, Tremors, Muscle Rigidity, Sialorrhea, Akinetic-Dysphonia, Akinetic Mutism, Oral Muscle and Limb Involuntary Movements, Muscle Tone Abnormalities, Stiff Neck, Facial Spasms, Pharyngeal Spasms, Uterine Spasms, Ocular Myoclonus, Opisthotonus, Fatty Liver, Regulatory Disorders, Blurred Vision, Photophobia, Constipation, Decreased Appetite, Gastritis, Gastroenteritis, Increased Appetite, Diarrhea, Epigastric Pain, Abdominal Pain, Gastrointestinal Disorders, Cheilitis, Elevated Prolactin, Menstrual Disorders, Galactorrhea, Ejaculation Disorders, Gynecomastia, Erectile Dysfunction, Dysuria, Urinary Retention, Incontinence, Frequency of Urination, Insomnia, Drowsiness, Anxiety, Nervousness, Anger, Dizziness, Lightheadedness, Mild Headache, Headache, Excitability, Aggression, Nightmares, Worsening of Schizophrenia, Over-sedation, Over-inhibition, Depression, Hallucinations, Auditory Hallucinations, Delusions, Paranoid Delusions, Sleep Disorders, Abnormal Behavior, Hyperactivity, Suicide Attempt, Abnormal EEG, Manic State, Altered Consciousness, Emotional Dysregulation, Paresthesia, Speech Disorders, Talkativeness, Tension, Seizures, Leukocytosis, Neutrophilia, Lymphocytopenia, Erythrocytosis, Anemia, Erythropenia, Hemoglobin Reduction, Hematocrit Reduction, Thrombocytosis, Thrombocytopenia, Atypical Lymphocytes, Generalized Weakness, Thirst, Feeling Weak, Edema, Water Intoxication, Hair Loss, Diabetes, Hypoglycemia, Upper Respiratory Tract Infection, Nasopharyngitis, Limb Pain, Sweating, Fever, Weight Gain, Weight Loss, Chest Pain, Cough, Hyperventilation, Rhinorrhea, Epistaxis, Dysphagia, Facial Edema, Aspiration Pneumonia, Hypothermia, Elevated CK, Elevated Triglycerides, Elevated Cholesterol in Blood, Elevated Insulin in Blood, Elevated Phospholipids in Blood, Increased Blood Sugar, Elevated BUN, Decreased BUN, Decreased Total Protein in Blood, Elevated Potassium in Blood, Decreased Potassium in Blood, Decreased Sodium in Blood, Positive Urine Protein, Positive Urine Urobilin, Positive Urine Glucose, Positive Urinary Hematuria, Thromboembolism, Pulmonary Embolism, Deep Venous Thrombosis, Delusions, Insomnia, Depression, Worsening of Schizophrenia, Hallucinations, Auditory Hallucinations, Brain Metastasis, Anxiety, Endometriosis, Uterine Fibroids, Suicide Attempt, Akinetic Mutism, Impulse Control Disorder, Cold, Dyspepsia, Aggression, Impulsive Behavior, Worsening of Obsessive-Compulsive Disorder, Dry Eyes, Dry Lesions, Conjunctivitis, Worsening of Aggression, Memory Impairment, Hyperreactivity, Arthralgia, Tinnitus, Leg Paresthesia, Back Pain, Fecal Incontinence, Retinal Vein Thrombosis, Bruising, Neck and Shoulder Pain, Body Aches, Cystitis, Sinusitis, Rhinitis, Kidney Stones, Facial Paralysis, Extraocular Muscle Disorder, Gastroesophageal Reflux, Seborrheic Dermatitis, Epistaxis, Worsening of Parkinson's Disease, Heaviness in Limbs, Fatigue, Scleroderma, Tongue Tremors, Epidermal Necrolysis, Lethargy

This medication should be stored in a tightly closed container to prevent air or moisture ingress. The storage temperature should be maintained at room temperature between 1 to 30 degrees Celsius.

Appearance

White round tablet

Package unit

30 tablets/bottle, 100 tablets/bottle