Tamin Extended-Release Tablet 16 mg (Galantamine Hydrobromide)

Adult dose

Administer once daily in the morning. It is best taken immediately after breakfast. Swallow this medicine whole with an adequate amount of water; do not chew or crush it. Ensure adequate fluid intake while taking this medicine. Initial dose: A dose of 8mg once daily is recommended for the first 4 weeks. Maintenance dose: - After the initial dose, administer 16mg once daily for at least 4 weeks. - Thereafter, the dose may be increased up to a maximum of 24mg once daily based on assessment of clinical benefit and tolerability. - If 24mg once daily is poorly tolerated or does not improve response, consider reducing the dose to 16mg once daily. - This medicine may be continued as long as it provides benefit to the patient. Assess its clinical benefit regularly and consider discontinuing treatment if there is no therapeutic effect. - No rebound phenomenon occurs after discontinuation of treatment (e.g., in preparation for surgery). Galantamine concentrations in the blood may increase in patients with moderate to severe renal or hepatic impairment. For patients with moderate hepatic impairment, based on pharmacokinetic modeling, administer 8mg every other day for at least 1 week; morning administration is preferable. Thereafter, administer 8mg once daily for at least 4 weeks. Do not exceed 16mg per day. This medicine is contraindicated in patients with severe hepatic impairment (Child-Pugh score >9). No dosage adjustment is necessary in patients with mild hepatic impairment. No dosage adjustment is necessary in patients with a creatinine clearance of 9mL/min or higher. This medicine is contraindicated in patients with severe renal impairment (creatinine clearance < 9mL/min). Consider reducing the dose of this medicine in patients receiving CYP 2D6 or CYP 3A4 inhibitors (e.g., ketoconazole).

Child dose

Use in children is not recommended.

This medication should not be used in patients with allergies to its ingredients or severe liver or kidney dysfunction. Various side effects such as nausea, vomiting, dizziness, headache, drowsiness, or bradycardia may occur during treatment with this medication, requiring caution. In particular, if severe skin rash or allergic reactions occur, discontinue use immediately and consult a physician. This medication is primarily used in patients with Alzheimer-type dementia; effectiveness in other types of dementia or cognitive impairment has not been confirmed. Weight loss may occur during treatment, so it is advisable to regularly monitor weight. Patients with heart diseases or slow heart rates and those with cardiac conduction disorders should be cautious as there could be heart-related issues when taking this medication. Patients with gastric ulcers or gastrointestinal diseases should closely observe symptoms while taking this medication, and it is not recommended for patients recovering from gastrointestinal surgery. Patients with asthma or pulmonary diseases should also exercise caution while taking this medication. Additionally, this medication may affect bladder function and is not suitable for patients recovering from bladder surgery or those with urinary disorders. When undergoing anesthesia, inform medical personnel that this medication may interact with muscle relaxants. This medication contains lactose, so it is not recommended for patients with lactose intolerance. Pregnant or nursing women should consult a physician before taking this medication as it may affect the fetus or infant. This medication may cause drowsiness or dizziness, requiring caution when driving or operating machinery. In case of overdose, severe symptoms such as nausea, vomiting, muscle weakness, and irregular heartbeats may occur; thus, dosage must be strictly adhered to, and if any unusual symptoms arise, immediate medical attention is required. Taking this medication together with other cholinergic medications may increase side effects, so it must be discussed with a physician or pharmacist. If taking other medications that affect drug metabolism, adjustments to the dosage of this medication may be necessary, so follow the instructions of a healthcare professional. Keep out of reach of children and store in the original container to maintain quality.

Decreased appetite, depression, dizziness, headache, tremors, fainting, drowsiness, sleepiness, bradycardia, nausea, vomiting, diarrhea, abdominal pain, epigastric pain, indigestion, abdominal discomfort, muscle spasms, fatigue, asthenia, lethargy, weight loss, falls, lacerations, dehydration, taste disorder, hypersomnia, sensory disturbance, blurred vision, I degree atrioventricular block, palpitations, bradyarrhythmia, ventricular premature beats, flushing, hypotension, nausea, sweating, muscle weakness, hypersensitivity, hallucinations, visual hallucinations, auditory hallucinations, convulsions, tinnitus, complete atrioventricular block, hypertension, hepatitis, Stevens-Johnson syndrome, acute generalized exanthematous pustulosis, erythema multiforme, increased liver enzymes, vertigo, decreased appetite, rash, pruritus, extrapyramidal syndrome, Parkinson's syndrome, exacerbation of Parkinson's syndrome, hand paralysis, bradykinesia, Pisa syndrome, delirium, sweating, edema, constipation, thirst, gastritis, belching, jaundice, increased γ-GT, elevated ALT/AST, exacerbation of chronic kidney failure, urinary incontinence, dizziness, drowsiness, severe nausea, gastrointestinal cramps, drooling, tearing, bowel movement, urination, exhaustion, Torsades de Pointes, QT prolongation, ventricular tachycardia, brief loss of consciousness

This medication should be stored in a sealed container to protect it from air or moisture. It is important to maintain a storage temperature between 1 degree and 30 degrees Celsius.

Appearance

Pink round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle