Clarithromycin Tablets

Adult dosage

Adults: The usual dose is 250mg (potency) of clarithromycin twice daily. For severe infections, administer 500mg (potency) twice daily. The usual duration of treatment is 7～14 days. In patients with renal failure and a creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer for more than 14 days to these patients. Mycobacterial infections: Administer 500mg (potency) of this medicine twice daily. In this case, it should be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, or rifampin. Eradication of Helicobacter pylori in patients with duodenal ulcer: Administer 500mg (potency) of this medicine 3 times daily with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) per dose 3 times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Children's dosage

Children 12 years of age and older: Same as adults. For children under 12 years of age, use clarithromycin dry syrup.

This medicine should not be administered to certain patients. For instance, it should not be used in patients with allergies to the ingredients contained in this medicine or to antibiotics of a similar class. Additionally, it should not be given to patients taking specific medications that may affect heart rhythm, or those with heart-related diseases, and to patients with severe liver or kidney impairment. It is also safer for pregnant or nursing women not to use this medicine. Serious side effects can occur when used with certain medications, so any currently taken medication must be discussed with medical personnel. Periodic checks of liver and kidney function should be performed during treatment, and any adverse reactions should be monitored. If symptoms such as rash, difficulty breathing, severe abdominal pain, or persistent diarrhea appear while using this medicine, discontinue use immediately and visit a medical institution. Prolonged use may lead to resistance; therefore, it should only be taken for the prescribed period as directed by the physician. Elderly patients, children, and those with weakened immune systems should use caution, and dosage adjustments may be necessary. This medicine may require caution during driving or operation of machinery, so careful consideration should be exercised during these activities. Overdose may result in gastrointestinal disturbance or central nervous system symptoms, so immediate consultation with medical personnel is recommended. Finally, this medicine should be stored under appropriate conditions, preferably in a dry place away from direct sunlight.

Shock, anaphylactic symptoms, dyspnea, convulsions, erythema, rash, pruritus, urticaria, skin erythema, angioedema, joint swelling, drug eruption, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, discomfort, flatulence, diarrhea, oral mucosal erosion, upper abdominal pain, thirst, tooth discoloration, pancreatitis, increased amylase, taste disturbance, anorexia, constipation, discoloration of stool, membranous colitis, hemorrhagic colitis, fever, cough, eosinophilia, eosinophilic pulmonary infiltration, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, disorientation, cognitive impairment, hallucinations, psychosis, depersonalization, tremor, paresthesia, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzyme levels, liver dysfunction, liver failure, fulminant hepatitis, increased AST, increased ALT, increased γ-GTP, increased LDH, increased ALP, increased total bilirubin, increased serum creatinine, increased BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, fatigue, headache, gustatory dysfunction, hearing loss, paresthesia, arthralgia, myalgia, olfactory disorder, hypoglycemia, purpuric rash, pustulosis, muscle spasms, musculoskeletal stiffness, myopathy, increased serum creatinine, increased blood urea, nephritis, venous thrombophlebitis at injection site, pain at injection site, inflammation at injection site, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, increased serum alkaline phosphatase, increased serum lactate dehydrogenase, increased INR, prolonged prothrombin time, abnormal urine color

This medicine is stored differently for domestic and export use. Domestic products should be placed in a sealed container and stored at room temperature between 1°C and 30°C. Export products should also be placed in a sealed container and stored in a dry place away from moisture and light at room temperature between 1°C and 30°C. Storing it this way will help maintain the effectiveness and safety of the medicine.

Appearance

[For domestic use] Yellow oval film-coated tablets [For export] Yellow rectangular film-coated tablets

Package unit

[For domestic use] 30 tablets/bottle, 100 tablets/bottle [For export] 20 tablets/PTP (10 tablets/PTP x 2)