ZeroFat Capsule (Orlistat)

Adult dose

The recommended dose of this medicine is 120 mg of orlistat orally 3 times a day, taken with a fat-containing meal or within 1 hour after a meal. Patients should continue to follow a nutritionally balanced, mildly hypocaloric diet in which approximately 30 % of calories come from fat. Daily intake of fat, carbohydrates, and protein should be distributed evenly among three meals. This medicine may be omitted if a meal is missed or contains no fat. Because this medicine may reduce the absorption of some fat-soluble vitamins and beta-carotene, patients are advised to take a multivitamin containing fat-soluble vitamins to ensure adequate nutrition. The vitamin supplement should be taken at least 2 hours before this medicine or at least 2 hours after it, such as at bedtime. Taking more than 120 mg of this medicine 3 times a day does not increase its effectiveness. Based on measurements of fecal fat, the effect of this medicine appears 24 ∼ 48 hours after administration. After discontinuation, fecal fat content generally returns to pretreatment levels within 48 ∼ 72 hours. The efficacy and safety of this medicine have not been evaluated for periods exceeding 4 years. Studies have not been conducted in patients with hepatic and/or renal impairment or in elderly patients.

Child dose

Studies have not been conducted in children under 12 years of age.

This medication should not be used in patients with chronic malabsorption syndrome or patients with biliary obstruction. Furthermore, it should not be administered to patients with allergies to this drug or its ingredients, to women who are pregnant or may become pregnant, and to nursing mothers. If liver damage is suspected, the doctor should be informed immediately, and the medication should be discontinued, while liver function tests should be performed to check the liver condition. Patients with hyperoxaluria or calcium oxalate kidney stones should be cautious when taking this medication. Taking this medication may frequently cause gastrointestinal symptoms, such as abdominal distension, flatulence, constipation, and oily stools, which are generally mild and transient. Gastrointestinal adverse reactions mainly occur within 3 months after the start of treatment and mostly improve within 1 to 4 weeks. Treatment may be discontinued due to adverse reactions, so patients should consult a doctor if symptoms are severe. This medication can increase gastrointestinal adverse reactions when a high amount of fat is consumed during meals, so it is important to distribute fat intake evenly throughout the three meals a day. Absorption of fat-soluble vitamins and beta-carotene may be reduced, so taking vitamin supplements is recommended, spaced at least 2 hours before or after taking this medication. If signs of liver dysfunction appear, the medication should be discontinued immediately, and medical attention should be sought, as severe liver damage like hepatitis or liver failure has been reported rarely. For diabetic patients, this medication may improve blood glucose control, necessitating adjustments to the doses of hypoglycemic agents. Excessive weight loss may increase the risk of gallstones, so caution is necessary. This medication may interact with certain drugs, so patients on cyclosporine, anticoagulants, antiepileptics, or antiretrovirals should consult healthcare professionals. Pregnant or nursing women should not take this medication, and safety in children under 12 years has not been established. This medication should be kept out of the reach of children and stored away from light and moisture.

• Fatty stool
• abdominal bloating and flatulence
• frequency of stools
• oily/fatty stools
• oily bowel movements
• increased bowel movements
• fecal incontinence
• abdominal pain/discomfort
• nausea
• infectious diarrhea

This medication is sensitive to air, light, and moisture, so it should be stored in a sealed container. It is also important to keep it in a cool place below 25 degrees Celsius to maintain its efficacy.

Appearance

A hard capsule with upper and lower teal green containing white or off-white powder or granules.

Package unit

90 capsules/box [(10 capsules/PTP) * 9], 30 capsules/bottle, 300 capsules/bottle