Aromasin 25mg (Exemestane)

Adult dose

The recommended dose for adults and older adults is 1 tablet of 25mg once daily, preferably after a meal. Continue treatment until tumor progression is clearly evident. There are no clinical studies of long-term administration in patients with renal or hepatic impairment. However, based on reports of moderate, nonfatal adverse reactions in clinical trials with doses up to 200mg, no dose adjustment is required, but administer with caution. In postmenopausal women with early breast cancer who have received tamoxifen for 2-3 years, continue treatment until cancer recurrence or development of cancer in the contralateral breast, for a total of 5 years including the period of tamoxifen treatment.

This medicine may be harmful to the fetus, so it should not be used by women who are pregnant or may become pregnant. There are no studies conducted in pregnant women in clinical trials, and exposure during pregnancy should be assessed for the risk of miscarriage and effects on the fetus. This medicine should be used only in postmenopausal women, and not in premenopausal or nursing women. Patients with poor liver or kidney function should use with caution. Patients with osteoporosis or at risk should undergo a bone density test prior to treatment and have regular monitoring during treatment. Vitamin D supplementation may be needed if there is a deficiency. Side effects such as hot flashes, joint pain, fatigue, nausea, and vomiting may occur, with rare reports of hepatitis, hair loss, and skin rashes. There may be risks of cardiovascular issues or gastrointestinal ulcers, and management should follow physician’s instructions. This medicine should be administered only after confirming menopause and should not be used alongside medications containing estrogen. Patients with specific sugar absorption disorders should not use this medicine, and allergic reactions are possible. Pregnant and lactating women should not use this medicine, and if taken while breastfeeding, immediate cessation of breastfeeding is required. It is not recommended for children, and no special dosage adjustment is needed for the elderly. In case of overdose, as there is no specific antidote, appropriate treatment and observation based on symptoms are required. Caution should be exercised when driving or operating machinery, as drowsiness, dizziness, or lethargy may occur. The medicine should be stored out of reach of children and should not be transferred to other containers.

Facial flushing, joint pain, fatigue, nausea, hypersensitivity, decreased appetite, depression, insomnia, headache, dizziness, carpal tunnel syndrome, paresthesia, abdominal pain, vomiting, nausea, diarrhea, constipation, dyspepsia, hyperhidrosis, rash, alopecia, urticaria, pruritus, acute generalized exanthematous pustulosis, joint and musculoskeletal pain, fractures, osteoporosis, trigger finger, adhesive tendonitis, pain, peripheral edema, increased liver enzymes, increased serum bilirubin, increased serum alkaline phosphatase, lymphocytopenia, thrombocytopenia, leukopenia, ischemic heart signs, hypertension, myocardial infarction, heart failure, gastric ulcer, cough, dyspnea, lymphedema, pharyngitis, sputum disorders, hyperuricemia, hypercholesterolemia, fever, anxiety, upper respiratory tract infection, palmoplantar erythema paresthesia, visual abnormalities, neuropathy, gastritis, laryngitis, rhinitis, anemia, increased C-reactive protein, liver neoplasm, herpes zoster, retrocecal appendicitis, unspecified gastrointestinal neoplasm, peripheral neuropathy, leukocytosis, abdominal enlargement, polyuria, neoplasm of unspecified behavior, deterioration of condition, peptic ulcer, gastroesophageal reflux, gingivitis, hyponatremia, hypoproteinemia, fatty liver, vaginal discharge, vaginitis, temperature sensation changes, periodontal destruction, decreased creatinine clearance, pneumonia, decreased prothrombin, dizziness, thrombocytosis, confusion, jaundice, drowsiness, hypersomnolence, lethargy

This medicine may be sensitive to air or moisture, so it should be stored in a tightly sealed container. Additionally, it is recommended to keep it in a cool place below 30 degrees Celsius to maintain efficacy.

Appearance

White to light yellow, round, convex film-coated tablet

Package unit

30 tablets (15 tablets/blister X 2)