Aridone Tablet 5 mg (Donepezil Hydrochloride Monohydrate)

Adult dose

○ Adults: Administer donepezil hydrochloride 5 mg once daily at bedtime. If sleep disturbances such as abnormal dreams, nightmares, or insomnia occur, taking this medicine in the morning may be considered. Since donepezil reaches steady state 15 days after administration and the frequency of adverse reactions may be affected by the rate of dose escalation, administer the 5 mg dose for 4~6 weeks. After evaluating the clinical response during this period, the dose may be increased to 10 mg. When increasing the dose to 10 mg daily, administer with caution for gastrointestinal adverse reactions. When administration of this medicine is discontinued, its effects gradually decrease, and no rebound effect occurs following abrupt discontinuation. ○ Female patients aged 85 years or older with low body weight: Careful monitoring is required because adverse reactions occur more frequently. Older women with low body weight should not exceed 5 mg daily.

Child dose

○ Children: There is no experience with use in children.

This medicine contains Donepezil Hydrochloride and is used for the treatment of Alzheimer's dementia. This medicine should be avoided in certain patients such as those who are allergic to Donepezil Hydrochloride or any of its components, pregnant or potentially pregnant women, and breastfeeding women. Patients with heart disease or conduction disorders should use this medicine with caution, as it may slow heart rate or cause arrhythmias. Patients with a history of peptic ulcers or those taking non-steroidal anti-inflammatory drugs (NSAIDs) should be careful since this medicine may increase gastric acid secretion and increase gastrointestinal motility, which can exacerbate symptoms. Patients with asthma or obstructive lung diseases should also use this medicine cautiously since it may increase bronchial constriction and mucus secretion. Patients with extrapyramidal disorders such as Parkinson’s disease should be aware that this medicine may worsen neurological symptoms. This medicine can cause various adverse reactions, and in severe cases, symptoms such as fainting, heart problems, gastrointestinal bleeding, liver dysfunction, neurological symptoms, movement disorders, neuroleptic malignant syndrome, and rhabdomyolysis may occur. Additionally, various neurological and psychiatric symptoms such as nausea, vomiting, diarrhea, dizziness, insomnia, hallucinations, anxiety, depression have been reported. If any abnormal symptoms arise during treatment, it is important to consult a healthcare professional immediately, and regular evaluations of treatment efficacy and side effects should be conducted. This medicine may affect driving or machine operation capabilities, so caution is required, especially during the initial stages of treatment or when changing the dose. Women who are pregnant or breastfeeding should ideally not use this medicine, and if necessary, they should consult a specialist and consider stopping breastfeeding. The safety of this medicine has not been established in children, so it is not used in pediatric patients. There are many potential drug interactions, so if you are taking other medications, you must inform your doctor or pharmacist, particularly when taking cardiac medications, antibiotics, antidepressants, and antipsychotics. In case of overdose, serious symptoms such as nausea, vomiting, sweating, bradycardia, hypotension, and respiratory depression may occur, necessitating immediate medical attention, and atropine may be used as an antidote. This medicine should be kept out of reach of children, and transferring it to other containers is not recommended for quality maintenance and safety reasons.

Syncope, bradycardia, heart block, prolonged QT interval, myocardial infarction, heart failure, peptic ulcer, perforated duodenal perforation, gastrointestinal bleeding, hepatitis, liver dysfunction, jaundice, cerebral seizure, cerebral hemorrhage, cerebrovascular disorder, motor dysfunction, ataxia, movement disorder, dystonia, tremor, involuntary movement, gait disturbance, abnormal posture, speech disorder, akinetic mutism, extreme muscle rigidity, dysphagia, tachycardia, blood pressure fluctuations, sweating, myalgia, weakness, dyspnea, acute pancreatitis, acute renal failure, unexplained sudden death, cold, appetite loss, hallucination, agitation, aggressive behavior, anxiety disorder, insomnia, drowsiness, increased libido, talkativeness, mania, nightmares, nervous hyperactivity, nonsense, delusion, depression, confusion, indifference, hyperactivity, hypersexuality, dizziness, tremor, seizure, stupor, thoracic rigidity, palpitations, sinoatrial block, atrioventricular block, hypertension, hypotension, atrial fibrillation, torsades de pointes ventricular tachycardia, diarrhea, nausea, vomiting, abdominal disorder, gastric ulcer, constipation, salivation, fecal incontinence, liver impairment, rash, pruritus, muscle spasms, urinary incontinence, frequent urination, urinary retention, headache, fatigue, pain, toothache, facial flushing, weakness, lethargy, edema, fever, decreased body temperature, decreased hematocrit, leukopenia, anemia, thrombocytopenia, petechiae, abnormal dreams, thought disorder, back pain, chest pain, bleeding, urinary tract infection, increased CPK, dehydration, hyperlipidemia, eczema, arthritis, arthrosis, bone fracture, arthralgia, leg cramps, osteoporosis, pharyngitis, pneumonia, increased cough, bronchitis, rhinitis, asthma, skin ulcer, psoriasis, skin discoloration, shingles, dry skin, urticaria, vesicular rash, conjunctivitis, glaucoma, visual disturbances, ear pain, tear abnormalities, cystitis, hematuria, diabetes, vaginitis, dysuria, proteinuria, agitation, cholecystitis, hemolytic anemia, hyponatremia, pancreatitis

This medicine should be stored in a tightly closed container to prevent air exposure, preferably at room temperature between 1 to 30 degrees Celsius. By storing it this way, the effectiveness of the medicine can be maintained for a long time.

Appearance

This medicine is a white, round, film-coated tablet.

Package unit

30 tablets/bottle