Orofenem 500 mg (Meropenem Hydrate)

Adult administration

As meropenem hydrate, administer 0.5 to 1 g (potency) daily divided into 2 to 3 doses via IV infusion over more than 30 minutes. For suspected infections in patients with pathogenic pneumonia, peritonitis, and neutropenia, administer 1 g (potency) via IV infusion every 8 hours. For cystic fibrosis and meningitis, administer 2 g (potency) via IV infusion every 8 hours.

Child administration

For bacterial meningitis in children over 3 months, administer 40 mg per kg of body weight every 8 hours via IV infusion over more than 30 minutes, depending on the pathogen's susceptibility and patient's condition.

This medication should not be administered to certain patients. For example, it should not be given to patients who have previously experienced shock related to this medication or patients taking sodium valproate alongside this medication. Additionally, patients who have had allergic reactions to this medication or its components, or those who have shown serious hypersensitivity reactions to other carbapenem antibiotics or beta-lactam antibiotics should be excluded from administration. Particular caution is required when administering to patients with impaired kidney function, those with epilepsy, liver disease, elderly patients, or those with poor general health or nutritional status. In particular, for infants under 3 months, safety and efficacy have not been established, so it must be used cautiously. During the administration of this medication, it is necessary to closely monitor the patient for various adverse reactions including shock, allergic reactions, blood abnormalities, liver or kidney function abnormalities, gastrointestinal disturbances, central nervous system symptoms, respiratory problems, and serious skin reactions. If a rash or other abnormal symptoms occur after administration, discontinue use immediately and seek appropriate treatment. To prevent the emergence of resistant bacteria, susceptibility testing should be conducted, and this medication should only be used for the minimum required duration. Furthermore, prior to administration, it is essential to check whether there has been a history of hypersensitivity to beta-lactam drugs, and during administration, liver and kidney function tests should be conducted regularly. This medication may interact with other drugs, so caution is needed, particularly when used with probenecid, antiepileptic medications, hormonal contraceptives, and warfarin. For women who are pregnant or may become pregnant, it should be administered only when the benefits of treatment outweigh the risks, and it is advisable to avoid use during breastfeeding. Elderly patients are more susceptible to side effects due to decreased physiological function, and there is a risk of bleeding due to vitamin K deficiency, so dosages and administration intervals should be adjusted carefully. This medication is for intravenous use only, and it should be used as soon as it is dissolved and should be consumed within the specified time during storage. Finally, this medication may have cross-allergic reactions with existing beta-lactam antibiotics, so caution is necessary if there is a history of drug allergy.

Serious side effects

Hives, severe swelling (edema), shock, anaphylaxis, severe allergic reactions, severe skin reactions (toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme, acute generalized exanthematous pustulosis), severe liver impairment, liver failure, jaundice, acute renal failure, severe kidney impairment, severe diarrhea (pseudomembranous colitis), seizures, altered consciousness, central nervous system symptoms, asthma, difficulty breathing, severe respiratory problems, heart failure, cardiac arrest, myocardial infarction, pulmonary.

Mild side effects

• Rash
• warmth
• erythema
• itching
• fever
• skin reddening
• generalized flushing
• angioedema
• oral abnormalities
• wheezing

This medication should be stored in a sealed container to prevent exposure to air or moisture. It is important to maintain a storage temperature between 1 degree and 30 degrees Celsius at room temperature to ensure that the medication retains its effectiveness.

Appearance

A white to pale yellow crystalline powder in a colorless, transparent vial for injection

Package unit

10 vials/box [1 vial x 10]