Donepezil Tablets 5 mg (Donepezil Hydrochloride Monohydrate)

Adult dose

○ Adults: Administer 5 mg of donepezil hydrochloride once daily before bedtime. If sleep disturbances such as unusual dreams, nightmares, or insomnia occur, taking this medication in the morning may be considered. Since donepezil reaches steady-state concentrations 15 days after administration and the frequency of adverse reactions may be affected by the rate of dose escalation, administer the 5 mg dose for 4~6 weeks. After evaluating the clinical response during this period, the dose may be increased to 10 mg. When increasing the dose to 10 mg daily, administer with caution for gastrointestinal adverse reactions. If this medication is discontinued, its effects gradually diminish, and no rebound effect occurs following abrupt discontinuation. ○ Female patients aged 85 years or older who are underweight: Careful monitoring is required because adverse reactions occur more frequently. Underweight elderly women should not exceed 5 mg daily.

Child dose

○ Children: There is no experience with use in children.

This medication contains Donepezil Hydrochloride and is used for the treatment of Alzheimer's disease symptoms. First, this medicine should not be used by individuals who are allergic to Donepezil Hydrochloride or similar substances, and by women who are pregnant, may become pregnant, or are breastfeeding. Patients with heart disease or cardiac conduction disorders should use this medication with caution, as it may slow the heart rate or cause arrhythmias. Additionally, patients with a history of peptic ulcers or those taking non-steroidal anti-inflammatory drugs should be cautious as gastrointestinal symptoms may worsen. Patients with asthma or obstructive pulmonary disease should also exercise caution as this medication may cause bronchospasm, worsening their symptoms. Patients with extrapyramidal disorders such as Parkinson's disease may require careful observation as this medication might exacerbate their symptoms. This medication can cause various side effects, and in severe cases, may lead to fainting, heart block, gastrointestinal bleeding, liver dysfunction, seizures, motor disorders, muscle abnormal symptoms, and more. Common mild side effects reported include nausea, vomiting, diarrhea, appetite loss, dizziness, insomnia, headache, and fatigue. Patients with heart disease or a history of prolonged QT interval may be at risk for arrhythmias and may require an electrocardiogram. This medication can affect driving or operating machinery, so caution should be applied during the initial dosing or dosage adjustments. Women who are pregnant or breastfeeding should avoid using this medication if possible, and use it only after consulting a healthcare professional if absolutely necessary. This medication may affect liver and kidney function, and regular testing may be required. In case of overdose, severe symptoms such as nausea, vomiting, bradycardia, respiratory depression may arise, and immediate medical attention should be sought. Atropine can be used as an antidote. Finally, this medication should be stored out of the reach of children and should not be transferred to other containers.

• Syncope
• bradycardia
• heart block
• prolonged QT interval
• myocardial infarction
• heart failure
• peptic ulcer
• perforated duodenal ulcer
• gastrointestinal bleeding
• hepatitis

This medication should be stored in a tightly closed container that prevents air entry and it is recommended to keep it at room temperature between 1 degree Celsius and 30 degrees Celsius. This will help maintain the efficacy of the medication for a longer duration.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle