Neuropezil 5 mg (Donepezil Hydrochloride Monohydrate)

Adult dose

Adults: Administer 5 mg of donepezil hydrochloride once daily at bedtime. If sleep disturbances such as unusual dreams, nightmares, or insomnia occur, taking this medicine in the morning may be considered. Since donepezil concentrations reach steady state 15 days after administration and the incidence of adverse reactions may be affected by the rate of dose escalation, administer the 5 mg dose for 4~6 weeks. After evaluating the clinical response during this period, the dose may be increased to 10 mg. When increasing the dose to 10 mg daily, administer with caution for gastrointestinal adverse reactions. If treatment with this medicine is discontinued, its effects gradually diminish, and no rebound effect occurs following abrupt discontinuation. Women aged 85 years or older with low body weight: Careful monitoring is required because adverse reactions occur more frequently. Elderly women with low body weight should not exceed 5 mg daily.

Child dose

Pediatric patients: There is no experience with use in pediatric patients.

This medication is used to alleviate the symptoms of Alzheimer's dementia and should not be given to individuals who are allergic to specific ingredients, pregnant women, or breastfeeding women. This drug contains lactose and should not be used in patients with lactose intolerance or certain genetic metabolic disorders. Patients with heart disease or issues such as heart conduction disorders or bradycardia should use this medication cautiously as it may affect the heart. Patients taking nonsteroidal anti-inflammatory drugs or with a history of peptic ulcers should administer this medication carefully, as it may increase gastric acid secretion and worsen symptoms. Patients suffering from asthma or obstructive pulmonary diseases need to be cautious as this medication may induce bronchoconstriction or worsen symptoms. Patients with extrapyramidal disorders like Parkinson's disease should use this medication carefully, as it may exacerbate their symptoms. While taking this medication, severe side effects such as abnormal heart symptoms, gastrointestinal bleeding, liver function abnormalities, seizures, movement disorders, and breathing difficulties may occur, so if any abnormal symptoms appear, it is essential to consult a healthcare professional immediately. Some patients may commonly experience side effects such as nausea, vomiting, diarrhea, decreased appetite, dizziness, insomnia, hallucinations, agitation, aggressive behavior, anxiety, talkativeness, mania, nightmares, irritability, delirium, delusions, depression, confusion, apathy, hyperactivity, increased libido, excessive libido, tremors, walking difficulties, involuntary movements, decreased concentration, mental dullness, eczema, itching, muscle cramps, myalgia, urinary incontinence, frequent urination, urinary retention, abdominal pain, weakness, and inflamed areas. This medication may affect driving or machine operation abilities, so caution is needed at the start of treatment or when changing dosages. Furthermore, this medication can interact with several other drugs, so patients should inform their healthcare provider if they are taking other medications, especially heart drugs, antibiotics, and antidepressants, as caution is necessary when used together. Pregnant or breastfeeding women are advised not to use this medication unless necessary and should discuss it with a healthcare provider beforehand. Safety in children has not been established, and as a principle, it should not be used in this population. In the case of overdose, symptoms such as nausea, vomiting, severe muscle weakness, and breathing difficulties may occur, and immediate emergency treatment should be sought, with atropine potentially used as an antidote. This medication should be stored out of reach of children, and transferring it to another container may cause degradation of quality or accidents, so caution is advised.

• Syncope
• bradycardia
• heart block
• QT interval prolongation
• myocardial infarction
• heart failure
• peptic ulcer
• perforated duodenal perforation
• gastrointestinal bleeding
• hepatitis

This medication should be stored in a sealed container to prevent air or moisture from entering. It is best to maintain a storage temperature between 1 and 30 degrees Celsius.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle