Glimel 4 mg Tablet (Glimepiride)

Adult dose

Administer orally once daily. Initiate treatment with a starting dose of 1 mg of glimepiride. Dosage may be increased by 1 mg at intervals of 1 to 2 weeks. Generally, there is little additional benefit beyond a dose of 4 mg, but if necessary, it may be increased to 6 mg or 8 mg. If dosing 4 mg daily fails, consider switching to or combining with insulin therapy.

This drug should not be used in patients with insulin-dependent diabetes or those presenting with diabetic ketoacidosis or diabetic coma. Patients with known allergies to this drug or its ingredients, or to sulfonylurea drugs should avoid taking it. There has been no experience with this drug in patients with severe liver or kidney impairment, and insulin treatment is recommended for these patients. Women who are pregnant or may become pregnant, as well as nursing mothers, should not take this drug. Patients with severe infections, before and after surgery, or those with severe trauma may require insulin therapy. Gastrointestinal disorders such as diarrhea or vomiting may lead to poor food absorption and increase the risk of hypoglycemia. This drug contains lactose and should not be used in patients with genetic issues such as galactose intolerance, certain lactase deficiency, or glucose-galactose malabsorption. During the first week of taking this medication, there is a heightened risk of hypoglycemia, so blood sugar levels should be closely monitored. Elderly patients, those with poor nutritional status or irregular eating habits, patients with unbalanced exercise and carbohydrate intake, those with changes in eating patterns, frequent alcohol users, patients with impaired kidney or liver function, those with other endocrine disorders, and patients taking other medications are at a higher risk of hypoglycemia and should be particularly cautious. Hypoglycemia can present with various symptoms such as headache, severe hunger, nausea, fatigue, anxiety, confusion, drowsiness, and loss of consciousness, and in severe cases, can result in a comatose state. If symptoms of hypoglycemia occur, sugar-containing food should be consumed immediately, and if symptoms are severe, medical attention should be sought immediately. Various side effects may arise from this medication, including temporary blurred vision, gastrointestinal disturbances, liver function abnormalities, blood abnormalities, and allergic reactions, so if any unusual symptoms occur, a consultation with a doctor or pharmacist is recommended. This medication should be taken regularly for blood sugar control, and dietary modifications and exercise should also be implemented. To prevent hypoglycemia, it is advisable to always carry a source of sugar (e.g., sugar, fruit juice). When taking other medications concurrently, one should inform their doctor or pharmacist as it may affect blood sugar levels. During pregnancy or breastfeeding, this drug should not be used, and insulin therapy should be considered instead. Overdose may cause hypoglycemia, so immediate vomiting should be induced or appropriate treatment should be sought at a hospital. This drug has not been proven safe and effective for children, and dosage adjustments may be necessary for the elderly depending on their kidney function. Finally, this drug should be stored out of the reach of children and kept in its original container.

Serious side effects

Hives, severe swelling (edema), itching, hypotension, shock, anaphylaxis, angioedema, skin and mucosal syndrome (Stevens-Johnson syndrome), biliary secretion disorders, jaundice, hepatitis, liver dysfunction, thrombocytopenia, thrombocytopenic purpura, leukopenia, hemolytic anemia, erythrocytopenia, granulocytopenia, agranulocytosis, pancytopenia, hemolytic anemia

Mild side effects

• Headache
• severe hunger
• nausea
• vomiting
• fatigue
• sleep disturbances
• anxiety
• aggression
• decreased concentration
• decreased agility or energy

This drug may be sensitive to air or moisture, so it should be stored in a sealed container. It is recommended to maintain storage temperatures between 1 and 30 degrees Celsius to preserve the drug's efficacy and safety for an extended period.

Appearance

This drug is a light blue, rectangular tablet.

Package unit

30 tablets/bottle, 100 tablets/bottle