Medication info
Kremin 28 Tablets

Kremin 28 Tablets

Prescription medication경구
Ingredient · strength
Cyproterone Acetate›1mgEstradiol Valerate›2mg
Manufacturer / importer
바이엘코리아(주)
Appearance
White round coated tablet and pink round coated tablet
Packaging
28 Tablets/PTP
Approval status
Active

MFDS item code 200800971 · Notified 2008.01.24 · Insurance code 641100820

Summary

Main use
Relief of symptoms of estrogen deficiency after menopause and effect of hormone replacement therapy
Who takes it
Adults · Children
Adult dose
On the first day of taking this medication, attach the sticker from the adhesive plate to align with the section marked "Start." Begin taking the tablet marked "Start" and consume one tablet daily for 28 days in the direction of the arrow. Take the white tablets for the first 16 days and the pink tablets for the following 12 days. Continuously take the new pack of medication the next day without interruption. Each tablet should be taken with adequate water.
Child dose
This medication is not intended for use in children and adolescents.

Ingredients

Importer
바이엘코리아(주)

Efficacy & effects

Relief of symptoms of estrogen deficiency after menopause and effect of hormone replacement therapy

  • Symptoms of estrogen deficiency
View approved original text

Hormone replacement therapy (HRT) is used to relieve various symptoms that occur as estrogen secretion decreases after menopause. This treatment helps alleviate various uncomfortable symptoms related to menopause, such as hot flashes, night sweats, and vaginal dryness. It also contributes to maintaining bone health and preventing osteoporosis. HRT can be safely used when appropriately adjusted according to the individual patient's condition. For this reason, it is used as an effective treatment for relieving symptoms of estrogen deficiency after menopause.

How to take

Adult dose

On the first day of taking this medication, attach the sticker from the adhesive plate to align with the section marked "Start." Begin taking the tablet marked "Start" and consume one tablet daily for 28 days in the direction of the arrow. Take the white tablets for the first 16 days and the pink tablets for the following 12 days. Continuously take the new pack of medication the next day without interruption. Each tablet should be taken with adequate water.

Child dose

This medication is not intended for use in children and adolescents.

Precautions

This medication should be stopped immediately and a doctor should be consulted if specific health conditions or symptoms arise. For example, sudden and severe headaches or visual or auditory disturbances, early symptoms of thrombosis, chest pain, or signs of liver disease indicate that administration should be discontinued immediately. Furthermore, this medication should not be administered to certain patients under any circumstances. For example, individuals who are allergic to this medication or its components, have severe liver dysfunction, liver tumors, are pregnant or breastfeeding, or have a history of thrombosis, may face risks if this medication is used. Patients with certain diseases or a history of conditions such as uterine fibroids, hypertension, diabetes, migraine, epilepsy, or asthma should be managed more carefully. Any unusual symptoms during treatment should be reported to a doctor immediately. There can be various side effects while taking this medication. Common symptoms may include headaches, dizziness, depressed mood, weight changes, indigestion, skin rash, and breast tenderness. Rarely, serious issues such as liver function abnormalities, thrombosis, breast cancer, and endometrial cancer may occur, so regular check-ups are necessary. This medication is not a contraceptive, and individual and family medical history must be thoroughly investigated before administration, along with blood pressure, blood sugar, liver function tests, and gynecological examinations. It is also important to confirm health status through regular examinations during treatment. This medication can interact with other medications, so it is essential to inform the doctor or pharmacist if other medications are being taken. In particular, when used with medications that alter drug metabolism in the liver, efficacy may vary. Pregnant or breastfeeding women should not use this medication, and should stop taking it immediately if pregnancy is confirmed. In case of overdose, symptoms such as breast tension, abdominal bloating, anxiety, nausea, or bleeding may occur, and since there is no specific antidote, appropriate treatment should be given according to symptoms. Finally, this medication should be kept out of reach of children and stored in its original container to prevent quality degradation or misuse.

Side effects and when to seek care immediately

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweats, pallor, severe rash with high fever, blisters, skin peeling, pain in oral/eye mucosa, difficulty or shortness of breath, asthma attacks, respiratory abnormalities associated with cough and fever, yellowing of the skin or eyes (jaundice), severe lethargy, sudden and severe headaches, thunderclap headache, seizures, confusion, visual disturbances, paralysis, urination

Mild side effects

Weight gain or loss, depressed mood, anxiety, decreased libido or increased libido, headaches, dizziness, migraines, visual disturbances, contact lens intolerance, palpitations, abdominal pain, nausea, indigestion, abdominal bloating, vomiting, rash, itching, erythema nodosum, hirsutism, acne, muscle cramps, spotting or bleeding from the uterus/vagina, breast pain, breast tenderness, menstrual pain, vaginal discharge, premenstrual syndrome, breast size increase, edema

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in a cool place below 25 degrees Celsius and kept in a tightly sealed container to prevent air from entering. This way, the effectiveness of the medication can be maintained for a longer time.

Appearance and packaging

Appearance

White round coated tablet and pink round coated tablet

Package unit

28 Tablets/PTP

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.