Pentasa Delayed-Release Granules 2 grams (Mesalamine)

Adult dose

1. Ulcerative colitis For adults, during acute episodes, administer up to 4g of mesalazine daily, either once daily or in 2~4 divided doses; for maintenance therapy, administer 2g orally once daily. 2. Crohn's disease For adults, administer up to 4g of mesalazine daily orally in divided doses.

Child dose

1. Ulcerative colitis Children aged 6 years and older: During acute episodes, administer 30~50mg/kg daily orally in divided doses. Children aged 6 years and older: For maintenance therapy, administer 15~30mg/kg daily orally in divided doses. The maximum daily dose for children should not exceed the recommended adult dose. For children weighing no more than 40kg, the recommended dose is half the adult dose. For children weighing 40kg, the recommended dose is equivalent to the usual adult dose. 2. Crohn's disease Children aged 6 years and older: During acute episodes, administer 30~50mg/kg daily orally in divided doses. Children aged 6 years and older: For maintenance therapy, administer 15~30mg/kg daily orally in divided doses. For children weighing no more than 40kg, the recommended dose is half the adult dose. For children weighing 40kg, the recommended dose is equivalent to the usual adult dose.

This medication should not be used in certain patients. Patients who are allergic to this medication, its ingredients, or salicylic acid or salicylates should not take it. Patients with severely impaired liver or kidney function, peptic ulcer, or issues with blood clotting should also avoid this medication. Children under 6 years of age should not take this medication, and patients who have had asthma attacks or other allergic reactions while taking salicylates or non-steroidal anti-inflammatory drugs (NSAIDs) should be cautious. Patients with severely uncontrolled heart failure or those taking significant amounts of a medication called methotrexate should also avoid this medication. Use this medication cautiously in patients with bronchial asthma, those allergic to other medications, individuals with weak liver or kidney function, patients with blood disorders, pregnant or nursing women, children and adolescents between 6 and 18 years of age, elderly patients, and those who have had an allergic reaction to sulfasalazine. During treatment, side effects such as diarrhea, nausea, abdominal pain, headache, vomiting, and skin rash may frequently occur. Occasionally, serious allergic reactions or severe skin rashes, mucosal damage, blood abnormalities such as high fever may occur; in such cases, consult a physician immediately. Regular blood tests, liver function tests, and urine tests should be conducted while using this medication, and kidney function should be monitored periodically. Patients with asthma or poor lung function should take this medication under thorough supervision by a physician. This medication may interact with other drugs, so caution is needed when taking it with NSAIDs, anticoagulants, steroids, methotrexate, etc. Pregnant or nursing women should carefully consider the risks and benefits of using this medication, and if diarrhea occurs in the baby while breastfeeding, they should stop breastfeeding. Safety and effectiveness should be carefully evaluated for children and adolescents using this medication, and elderly patients may require a lower starting dose and frequent blood tests due to potentially reduced liver and kidney function. In cases of overdose, there is no specific antidote, and symptomatic treatment such as inducing vomiting, gastric lavage, and correction of fluid and electrolyte balance will be administered. This medication should be swallowed whole and not chewed; if necessary, it can be taken mixed with water or juice. When storing this medication, it should be kept out of reach of children, and it is recommended not to transfer it to another container.

Diarrhea, nausea, abdominal pain, headache, vomiting, rash, hypersensitivity reaction, Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS syndrome), Stevens-Johnson syndrome (SJS), Toxic Epidermal Necrolysis (TEN), anemia, aplastic anemia, agranulocytosis, neutropenia, leukopenia, pancytopenia, thrombocytopenia, anaphylaxis, dizziness, peripheral neuropathy, idiopathic intracranial hypertension, myocarditis, pericarditis, dyspnea, cough, bronchospasm, allergic alveolitis, pulmonary eosinophilia, interstitial lung disease, pulmonary infiltration, pneumonia, pleuritis, bloating, increased amylase, acute pancreatitis, colitis, elevated aminotransferases, increased parameters of cholestasis, hepatotoxicity, hepatitis, cholestatic hepatitis, cirrhosis, liver failure, urticaria, erythematous rash, photosensitivity, hair loss, allergic rash, erythema multiforme, myalgia, arthralgia, erythema nodosum, renal dysfunction, nephrolithiasis, urine discoloration, reversible oligospermia, abdominal distension, belching, increased methemoglobin levels, conjunctivitis, benign intracranial hypertension in adolescents, angioedema

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. Storage temperature should be maintained at room temperature between 1 degree and 30 degrees.

Appearance

Grayish-white to light brown cylindrical granules

Package unit

60 packets/box