Bonseive 35 mg Tablet (Sodium Risedronate)

Adult dose

Adults: Administer 35 mg of risedronate sodium orally once weekly. No dosage adjustment is necessary in elderly patients (over 60 years) because the bioavailability and pharmacodynamics of this drug are similar to those in younger people. No dosage adjustment is necessary in patients with a creatinine clearance of 30 mL/min or higher. This drug is contraindicated in patients with severe renal impairment and a creatinine clearance below 30 mL/min. Food interferes with the absorption of this drug. For adequate absorption, take it at least 30 minutes before breakfast or at least 2 hours before or after consuming food or beverages at any time of day. To help the drug reach the stomach easily and reduce the possibility of esophageal irritation, take it in an upright position with a sufficient amount of plain water (170 ∼ 230 mL). Taking this drug with other beverages, including mineral water, may reduce its absorption. Do not chew or suck this drug because of the possibility of oropharyngeal ulceration. Patients should not lie down for at least 30 minutes after taking it. If a patient forgets to take a dose on the scheduled day, take it the next morning when remembered. Resume the usual dosing schedule on the next scheduled day. Do not take 2 tablets on the same day.

Child dose

Children under 18 years: Safety and efficacy have not been established.

This medication can irritate the mucosa of the stomach and esophagus, so patients with upper gastrointestinal diseases such as gastritis or esophageal disorders should be particularly careful. Take with a sufficient amount of water and do not lie down for a certain period after taking it to reduce esophageal irritation. If symptoms such as pain in the esophagus, difficulty swallowing, or heartburn occur, stop taking the medication immediately and consult a doctor. This medication should not be administered to certain patients, including those with esophageal strictures, hypocalcemia, pregnant or breastfeeding women, and those with severe kidney disorders. Additionally, patients with genetic issues such as lactose intolerance should avoid taking this medication. It is important to ensure adequate intake of calcium and vitamin D while taking this medication, and patients receiving long-term corticosteroid treatment should be particularly cautious. During treatment, it is advisable to avoid taking this medication with food or drugs containing divalent cations and to avoid eating for a certain period before and after taking the medication. This medication can rarely cause serious side effects such as osteonecrosis of the jaw, atypical femoral fractures, and severe bone, joint, and muscle pain, so if symptoms occur, immediate medical attention is required. Pregnant women or women who may become pregnant and nursing mothers should not take this medication, as it may also be secreted in breast milk. Safety and efficacy have not been established in children under 18, and it can be used in elderly patients without special differences. In cases of overdose, blood calcium and phosphorus levels may drop, and symptoms of hypocalcemia may occur, requiring immediate treatment. Keep this medication out of reach of children and do not transfer it to other containers for safety.

• esophagitis
• esophageal ulcer
• esophageal erosion
• esophageal obstruction
• esophageal perforation
• bleeding
• infection
• back pain
• accidental injury
• pain

Store this medication in a tightly closed container to prevent exposure to air or moisture. It is also important to keep it at a room temperature between 1°C and 30°C to maintain the medication's effectiveness.

Appearance

Pale orange round film-coated tablet

Package unit

4 tablets/PTP