Clobain Tablets (Clopidogrel Hydrogen Sulfate)

Adult dose

○ Adults 1. For patients with ischemic stroke, myocardial infarction, or peripheral arterial disease, administer clopidogrel 75 mg orally once daily. 2. For patients with acute coronary syndrome (unstable angina or non-Q-wave myocardial infarction), begin treatment on the day this medicine is initiated with a loading dose of 300 mg once daily, followed by an oral maintenance dose of 75 mg once daily. Aspirin 75 ～ 325 mg should be administered concomitantly with this medicine once daily. 3. For patients with atrial fibrillation, administer this medicine 75 mg orally once daily. Aspirin 75 ～ 100 mg should be administered concomitantly with this medicine once daily. ○ Patients with renal impairment : Experience with treatment in patients with renal impairment is limited. ○ Patients with hepatic impairment : Experience with treatment in patients with moderate hepatic disease and a bleeding diathesis is limited. This medicine may be administered with or without food.

This medication helps to prevent platelets from aggregating, thereby facilitating blood flow. Individuals with a genetic deficiency in a specific enzyme (CYP2C19) may find that this medication does not work effectively, and they may be more susceptible to cardiovascular issues such as heart attacks. In such cases, alternative treatment options should be discussed with a physician. Moreover, taking this medication with drugs that activate this enzyme may excessively enhance its effects, increasing the risk of bleeding, so concurrent usage is not advised. Do not use this medication in patients with allergies to it, patients with bleeding disorders, patients with severe liver dysfunction, nursing mothers, and patients with genetic issues like lactose intolerance. Patients at risk of bleeding, blood coagulation problems, or those who have undergone recent surgery should use this medication cautiously and should inform their physician immediately of any bleeding symptoms. If surgery is planned, discontinue this medication 5 to 7 days prior. This medication may increase the risk of bleeding, so caution is needed when taken with other anticoagulants (e.g., aspirin, nonsteroidal anti-inflammatory drugs, thrombolytics, specific antidepressants, etc.). While taking this medication, there may be an increased occurrence of bleeding; if there are any bleeding sites or if bleeding durations are longer than usual, inform a physician promptly. During pregnancy, while the risk to the fetus is low, there is a risk of bleeding during delivery, so discontinue the medication 5 to 7 days before the expected delivery date. If nursing, this medication may pass into breast milk, so consult a physician regarding whether to continue breastfeeding or discontinue the medication. Safety and efficacy in children have not been established. Elderly individuals may have decreased bodily functions, leading to a higher risk of bleeding, thus requiring dosage adjustments and close monitoring of their condition. Overdose may increase the risk of bleeding, and as there are no specific antidotes, emergency treatment may involve platelet transfusion. Keep this medication out of the reach of children, and do not transfer it to other containers.

hemorrhage, gastrointestinal bleeding, hospitalization required hemorrhage, purpura, contusion, hematoma, epistaxis, hematuria, intraocular hemorrhage, intracranial hemorrhage, significant hemorrhage, life-threatening hemorrhage, fatal hemorrhage, hemorrhagic stroke, need for laxative use, requirement for transfusion, thrombocytopenia, neutropenia, aplastic anemia, abdominal pain, dyspepsia, diarrhea, rash, pruritus, chest pain, accidental injury, influenza-like illness, pain, fatigue, edema, hypertension, headache, dizziness, nausea, depression, upper respiratory tract infection, dyspnea, rhinitis, bronchitis, cough, urinary tract infection, decreased motor function, tremor, speech disorder, abnormal gait, hyperkinesia, ataxia, sensory disturbance, insomnia, depression, forgetfulness, anxiety, confusion, thought disorder, abnormal behavior, arthralgia, myalgia, low back pain, weight loss, weight gain, facial flushing, weakness, rigidity, facial edema, syncope, purpura, bloody stools, hematoma, hemoptysis, muscle hemorrhage, gingival bleeding, pneumonia, sinusitis, visual disturbance, visual impairment, dry eyes, temporary blindness, congestion, tinnitus, urinary dysfunction, frequency of urination, non-protein nitrogen increase, uremia, increased blood urea nitrogen, hypoglycemia, hyperuricemia, increased liver enzymes, ALT elevation, abnormal liver function, leg edema, arrhythmia, bradycardia, palpitations, contact dermatitis, gynecomastia, increased prostate-specific antigen, allergic symptoms, ischemic necrosis, gastritis, hemorrhagic gastroenteritis, duodenal ulcer, gastric ulcer, perforated gastric ulcer, upper gastrointestinal ulcer bleeding, abdominal distension, hyperbilirubinemia, infectious hepatitis, fatty liver, hemorrhagic arthropathy, hematuria, hemoptysis, retroperitoneal hemorrhage, surgical wound bleeding, pulmonary hemorrhage, vasculitis, hypotension, bronchospasm, interstitial pneumonia, eosinophilic pneumonia, colitis, pancreatitis, stomatitis, hepatitis, acute liver failure, herpes zoster, erythematous rash, maculopapular rash, urticaria, itching, angioedema, vesicular dermatitis, drug-induced hypersensitivity syndrome, drug rash with eosinophilia and systemic symptoms, eczema, lichen planus, glomerulonephritis, fever, abnormal liver function tests, increased blood creatinine, cholecystitis, hematemesis, spinal hematoma

This medication may degrade due to air or moisture; therefore, it must be stored in a tightly sealed container. The appropriate storage temperature is between 1 degree and 30 degrees Celsius in a room.

Appearance

Pink round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle