Amaryl M Tablets 1/500 mg

Adult dose

This medication is administered 1 to 2 times a day, immediately before or with meals. The dose can be adjusted considering each patient’s current therapy, efficacy, and tolerability, and appropriate blood sugar monitoring should be conducted for this. Typically, treatment is started at a low dose, and the dose can be adjusted based on the patient’s current medication and blood sugar levels. In clinical trials, the initial daily dose was glimepiride/metformin hydrochloride.

This medication carries the risk of severe lactic acidosis or hypoglycemia; therefore, treatment should be discontinued, and consultation with a doctor is necessary if there is a significant decline in kidney function or dehydration. This medication should not be used in patients with poor kidney function, liver dysfunction, severe infections, or those undergoing surgery. Elderly patients, those with poor nutritional status, or patients with erratic eating habits are at higher risk of hypoglycemia and should be more cautious. While taking this medication, gastrointestinal symptoms (diarrhea, nausea, vomiting, etc.) may occur, but they are usually temporary and can be alleviated by taking the medication with food. Symptoms of hypoglycemia include headaches, severe hunger, fatigue, and dizziness; if these symptoms appear, sugar should be taken immediately, and consultation with healthcare providers is necessary. The risk of lactic acidosis increases when this medication is taken with alcohol, so excessive drinking should be avoided. Regular checks on blood sugar, kidney function, liver function, and vitamin B12 levels are important to ensure there are no abnormalities. This medication may interact with other drugs; therefore, patients should inform their healthcare providers about any other medications being taken and be closely monitored. It is safer for pregnant or breastfeeding women not to use this medication, and switching to insulin therapy is recommended if necessary. In cases of overdose, hypoglycemia or lactic acidosis may occur, so immediate medical attention is required for proper treatment. Caution is needed when driving or operating machinery, as hypoglycemia or impaired agility can occur.

Serious side effects

Hives, severe swelling (edema), difficulty breathing, severe allergic reactions, liver dysfunction, hepatitis, jaundice, sudden and severe headaches, seizures, confusion, paralysis, thrombocytopenia, leukopenia, hemolytic anemia, erythrocytopenia, agranulocytosis, pancytopenia, thrombocytopenic purpura, increased risk of cardiovascular mortality, hypoglycemia, severe hypoglycemic symptoms (loss of consciousness, coma, etc.), cardiac arrest.

Mild side effects

• Diarrhea
• nausea
• vomiting
• abdominal bloating
• loss of appetite
• dyspepsia
• constipation
• abdominal pain
• metallic taste
• visual impairment

This medication should be stored in a tightly sealed container to prevent air entry, and it is best kept at room temperature between 1°C and 30°C. Storing it this way can preserve the effectiveness and safety of the medication for a longer period.

Appearance

Light pink, kidney-shaped, convex film-coated tablet (for oral use)

Package unit

100 tablets/bottle, 30 tablets (10 tablets/PTP x 3)