Ceftriaxone Sodium Hydrate 1.5g

Adult administration

For adults and children over 12 years old, administer 1 to 2 g (activity unit) of ceftriaxone once daily via IV or IM injection. For infections caused by pathogens exhibiting moderate to severe susceptibility, the dose can be escalated up to 4 g (activity unit) once daily. For gonorrhea treatment, a single IM injection of 250 mg (activity unit) is recommended. To prevent infections before and after surgery, administer 1 to 2 g (activity unit) once, 30 to 90 minutes before the procedure.

Child administration

For neonates (up to 14 days old), administer 20 to 50 mg (activity unit) per kg of body weight once daily, not exceeding 50 mg (activity unit) per kg. For infants and children (15 days to 12 years old), administer

This medication should not be mixed with or administered concurrently with calcium-containing solutions or other medications. Especially in newborns under 28 days old, the combination of calcium and this medication can create precipitates and pose risks, hence it should not be administered. If a newborn or premature infant is given this medication along with calcium-containing solutions, precipitates may form in the lungs or kidneys, leading to fatal outcomes. Patients with hypersensitivity to this medication or allergies to cephalosporin or penicillin antibiotics should not use it. This medication, containing lidocaine, should not be administered intravenously and should also not be given to newborns with bilirubin binding issues. Care should be taken when administering this medication to individuals with known allergy histories or allergic conditions like bronchial asthma and to patients with severe kidney impairment. Additionally, patients who are at risk of vitamin K deficiency should have their prothrombin times frequently checked or receive vitamin K supplementation as needed. This medication may commonly cause changes in blood cell counts, diarrhea, rash, abnormal liver function, and rarely severe allergic reactions, kidney dysfunction, and central nervous system abnormalities. Patients' conditions must be closely monitored during administration, and if any adverse symptoms occur, treatment must be immediately halted and appropriate management must be provided. Caution is advised when using this medication in conjunction with other cephalosporins, diuretics, and aminoglycoside antibiotics as it may increase nephrotoxicity. Additionally, co-administration with calcium can present a risk of precipitation, therefore they should not be given simultaneously, and the infusion line should be thoroughly cleaned if necessary. Pregnant or breastfeeding women should use this medication with caution as it may affect the fetus or newborn. In particular, newborns and premature infants are at risk for bilirubin encephalopathy and should not be given this medication. Elderly patients may experience more pronounced side effects due to decreased physical function, so dosage and administration intervals should be adjusted, and close observation is required. This medication may also affect blood glucose tests or urine sugar tests, necessitating careful selection of testing methods. Injection sites may experience pain or phlebitis, thus injection techniques and rates must be adjusted with care, and prepared solutions should be used as soon as possible.

Serious side effects

• Urticaria
• severe swelling (edema)
• difficulty breathing
• severe allergic reactions
• severe skin reactions
• encephalopathy
• serious neurological symptoms
• severe skin reactions
• Stevens-Johnson syndrome
• toxic epidermal necrolysis

Mild side effects

• Eosinophilia
• leukopenia
• thrombocytopenia
• diarrhea
• rash
• elevated liver enzymes
• headache
• dizziness
• bronchospasm
• loose stools

This medication should be stored in a sealed container that is air-tight and kept at a temperature between 1 to 30 degrees Celsius. Proper storage conditions will help maintain the medication's efficacy for a long time.

Appearance

A colorless and transparent vial filled with white or pale yellow crystalline powder.

Package unit

1 vial × 10 pieces