Aloksijoo (Palonosetron Hydrochloride)

Adult administration

1. Adults 1) Prevention of nausea and vomiting induced by cancer chemotherapy: Administer palonosetron 0.25 mg as a single intravenous injection over at least 30 seconds, 30 minutes before the start of chemotherapy. 2) Prevention of postoperative nausea and vomiting: Administer 0.075 mg as a single intravenous injection over at least 10 seconds immediately before induction of anesthesia. As with other antiemetics, routine administration is not recommended for patients expected to have a low likelihood of postoperative nausea and vomiting. Administration of this drug is recommended for patients in whom postoperative nausea and vomiting should be avoided, even if the likelihood of postoperative nausea and vomiting is low. 3) Treatment of postoperative nausea and vomiting: As soon as nausea and vomiting occur, administer 0.075 mg as a single intravenous injection over at least 10 seconds. 3. No specific dose adjustment is necessary for elderly patients or patients with hepatic or renal impairment. Clinical data are not available for patients with end-stage renal disease undergoing dialysis.

Child administration

Children (2 months and older) 1) Prevention of acute nausea and vomiting induced by cancer chemotherapy: Administer palonosetron 0.02mg/kg (maximum 1.5mg) as a single intravenous infusion over at least 15 minutes, 30 minutes before the start of chemotherapy. Neonates: The safety and efficacy of this drug have not been established (no data are available). Infants (under 24 months): Data on the use of this drug for the prevention of nausea and vomiting induced by cancer chemotherapy are limited.

This medication should not be used in patients who are allergic to it or its components. Patients who have had allergic reactions to similar drugs should be cautious when taking this medication. This drug may slow intestinal motility, and patients with constipation or signs of bowel obstruction should be monitored carefully while using it. Patients taking other serotonin-related medications should be monitored closely for the serious side effect known as serotonin syndrome. This medication is used to prevent or treat nausea and vomiting related to chemotherapy or surgery, and side effects such as headaches, constipation, diarrhea, dizziness, and fatigue may occur. Patients with heart conditions should be cautious as abnormal heart rhythms or blood pressure changes may occur rarely. Dizziness or drowsiness may occur when driving or operating machinery, so caution is needed. The safety of this medication during pregnancy has not been sufficiently established; it should only be used when absolutely necessary, and breastfeeding mothers should consult a healthcare professional since the drug may pass into breast milk. It can be used in children and elderly patients, but safety and efficacy have not been fully established in children, and while no special dosage adjustments are required for the elderly, their conditions should be carefully monitored. There is no specific antidote in case of overdose, so immediate contact with medical personnel is necessary for appropriate treatment. This medication should be stored away from light and freezing and kept at room temperature, ensuring there is no discoloration or foreign matter before administration. The interaction potential with other medications is low, but caution is needed when using it with serotonergic drugs due to the risk of side effects.

• Headache
• constipation
• diarrhea
• dizziness
• fatigue
• abdominal pain
• insomnia
• non-sustained tachycardia
• bradycardia
• hypotension

This medication should be stored at room temperature between 1 and 30 degrees Celsius, in a tightly sealed container to prevent air ingress. It is also recommended to store it in a dark place to avoid direct sunlight in order to maintain the drug's effectiveness.

Appearance

A colorless, transparent liquid in a colorless, transparent glass vial injection

Package unit

5 vials (1.5 mL/1 vial), 1 vial (1.5 mL/1 vial), 1 vial (5 mL/1 vial)