Clarithromycin Tablets

Adult dose

○ Adults Clarithromycin is usually administered at 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The usual duration of treatment is 7～14 days. In patients with renal impairment and creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer for more than 14 days in these patients. ○ Mycobacterial infections Administer 500mg (potency) of this medication twice daily. In this case, it should be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcer Administer 500mg (potency) of this medication three times daily in combination with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for an additional 14 days. That is, administer clarithromycin 500mg (potency) three times daily for 14 days (days 1–14) and omeprazole 40mg once daily for 28 days (days 1–28).

Child dose

Children aged 12 years and older: Same as adults Children under 12 years of age: Use clarithromycin dry syrup.

This medication should not be administered to certain patients. For example, individuals who are allergic to any component contained in this medication or have previously shown hypersensitivity to similar antibiotics should refrain from taking it. Moreover, it is also advised that patients with certain heart diseases, liver dysfunction, severely impaired kidney function, as well as pregnant or breastfeeding women do not use this medication. Serious side effects may occur if this medication is taken with certain other drugs; thus, if you are currently taking any medications, you must consult with a physician or pharmacist. This medication can affect liver and kidney function, so patients with liver or kidney diseases should take caution. Elderly patients or individuals with heart conditions also require special attention when using this medication. During the course of treatment, allergic reactions, severe skin rashes, digestive issues, breathing difficulties, neurological symptoms, etc., may manifest; if any of these symptoms occur, it is imperative to discontinue use immediately and inform healthcare professionals. Additionally, prolonged or excessive use may lead to hearing loss, tinnitus, liver function impairment, and muscle issues, necessitating regular examinations. This medication has numerous drug interactions, and dosage adjustments or caution may be required based on concomitant medications, so it is crucial to inform healthcare providers of all currently used medications. It is advised that pregnant or breastfeeding women do not use this medication, and if its use is unavoidable, they should consult with a healthcare professional. In children, the safety and effectiveness of this medication have not been sufficiently studied, so it should be administered cautiously. In cases of overdose, gastrointestinal disturbances or neurological symptoms may arise; therefore, it is essential to adhere to the prescribed dosage and visit a medical institution if any unusual symptoms occur. During treatment with this medication, if gastrointestinal symptoms such as diarrhea or abdominal pain persist, it is crucial to consult healthcare professionals immediately. Lastly, this medication must be stored under appropriate conditions, especially the dry syrup formulation, which should be kept at room temperature and not refrigerated.

Shock, anaphylactic symptoms, dyspnea, convulsions, flushing, rash, itching, urticaria, mild skin erythema, angioedema, joint swelling, drug rash, abdominal bloating, nausea, vomiting, dyspepsia, abdominal pain, malaise, gas retention, diarrhea, oral mucosal erosion, upper abdominal pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, taste disturbance, decreased appetite, constipation, discoloration of stool, membranous colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, acute exacerbation of acute maxillary sinusitis, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremors, numbness, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug-induced rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, elevated liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, increased AST, increased ALT, elevated γ-GTP, increased LDH, increased ALP, elevated total bilirubin, increased serum creatinine, increased BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, lethargy, headache, taste disorder, hearing loss, paresthesia, arthralgia, myalgia, olfactory disorder, hypoglycemia, tinnitus, hearing impairment, purpuric rash, acute generalized exanthematous pustulosis, injection site phlebitis, injection site pain, injection site inflammation, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, increased blood lactic dehydrogenase, increased INR, prolonged prothrombin time, urine discoloration, vasodilation, cardiac arrest, atrial fibrillation, electrocardiogram QT prolongation, ectopic beats, palpitations, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, tooth discoloration, rash, hyperhidrosis, vesicular dermatitis, papular rash, acne, Henoch-Schonlein purpura, muscle cramps, musculoskeletal rigidity, myopathy, elevated blood urea nitrogen, nephritis

This medication should be stored in a tightly sealed container to protect it from air and moisture, preferably at a temperature between 1 degrees and 30 degrees Celsius. Proper storage will maintain the effectiveness and safety of the medication.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle