Wondran Tablet

Adult dose

Children aged 12 years and older and adults: The dosage should be adjusted according to the patient's level of pain and treatment response. A starting dose of 2 tablets is recommended, with a minimum interval of 6 hours between doses, not exceeding 8 tablets per day. Administer the lowest effective dose for as short a duration as necessary. Avoid administering this medication longer than necessary due to the nature and severity of the condition; if prolonged treatment is required, regular monitoring should be conducted to verify the continued need for this medication. Elderly patients Administer the usual adult dose. However, for elderly patients over 75 years, the elimination half-life of tramadol may increase by 17% when administered orally, thus doses should be spaced at least 6 hours apart. Renal impaired patients For patients with moderate renal impairment (creatinine clearance of 10-30 ml/min), extend dosing intervals to every 12 hours. Administration is not recommended for patients with severe renal impairment (creatinine clearance below 10 ml/min). Tramadol is removed very slowly during dialysis and filtration, so it is not necessary to re-administer this medication post-dialysis for analgesic effect retention. Liver impaired patients Carefully consider extending dosing intervals for patients with moderate hepatic impairment. Do not administer this medication to patients with severe hepatic impairment.

Child dose

Children aged 12 years and older and adults: The dosage should be adjusted according to the patient's level of pain and treatment response. A starting dose of 2 tablets is recommended, and subsequent dosages should be spaced at least 6 hours apart, but not to exceed 8 tablets per day.

This medication may strain the liver, so those who consume alcohol in amounts exceeding a certain limit daily should consult a physician or pharmacist before taking it. While taking this medication, skin rashes or blisters, and severe allergic reactions may occur, so if these symptoms appear, discontinue use immediately and consult a healthcare professional. The ingredients in this medication may increase the risk of seizures; therefore, those with a history of seizures or a high risk of seizures should take it cautiously. Severe allergic reactions can rarely occur; if breathing difficulties or severe skin reactions manifest, immediate emergency treatment is required. For patients with severe respiratory diseases, the use of this medication may pose risks, and it should be administered under medical supervision. Taking this medication with alcohol or central nervous system depressants may cause severe drowsiness or respiratory depression, so caution is needed when co-administering. Patients with head injuries or brain diseases need to be cautious when taking this medication as it may increase intracranial pressure or risk of respiratory depression. This medication may cause physical and psychological dependence, so careful monitoring for dependency is necessary during prolonged use. Patients with poor liver function must consult a physician before taking this medication and avoid exceeding the recommended dosage. Patients with certain genotypes may experience faster metabolism of this medication, leading to an increased risk of respiratory depression; thus, special attention and monitoring are required during use. This medication should not be administered to children, especially those under 12 years old or children post certain surgeries; adolescents over 12 years should also avoid it if there are risk factors. This medication may exacerbate sleep apnea or hypoxemia; therefore, if related symptoms are present, consider dose adjustment or discontinuation. Elderly patients or those at risk of hyponatremia should regularly monitor for symptoms of hyponatremia while taking this medication. This medication may interact with specific drugs, so if you are taking other medications, always inform your healthcare provider. Women who are pregnant or breastfeeding should consult a physician before taking this medication, and it is safer not to administer it while breastfeeding. This medication can cause drowsiness or dizziness, so caution is advised when driving or operating machinery after taking it. In cases of overdose, severe respiratory depression or liver damage may occur, so the prescribed dosage must always be adhered to, and in case of overdose, immediate medical attention is required. Store in a secure place out of reach of children to prevent accidental ingestion.

Serious side effects

Hives, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor, high fever with severe rash, blisters, skin peeling, pain in mouth/eyes mucous membranes, shortness of breath or difficulty breathing, asthma attack, respiratory abnormalities accompanying cough and fever, jaundice (yellowing of the skin or eyes), generalized extreme fatigue, sudden and severe headache, lightning-like headache, seizures, altered consciousness, vision abnormalities, paralysis, significantly reduced urine output

Mild side effects

• Loss of appetite
• insomnia
• depression
• dizziness
• headache
• drowsiness
• nausea
• vomiting
• constipation
• dry mouth

This medication should be stored in a sealed container to prevent air and moisture exposure and is best kept at room temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the medication's efficacy and prevent deterioration.

Appearance

Light yellow oblong film-coated tablets

Package unit

For domestic use: 100 tablets/bottle, for export: 30 tablets/bottle, 100 tablets/bottle, 100 tablets (10 tablets/PTP x 10)