Abactam 500 mg (Amoxicillin/Clavulanate)

Adult dose

500 to 1000 mg (potency) of amoxicillin and clavulanate, taken orally 3 times a day.

Child dose

Children aged 12 years and older: 500 to 1000 mg (potency) of amoxicillin and clavulanate, taken orally 3 times a day.

This medication is a penicillin-class antibiotic that should not be used in patients with specific allergies or hypersensitivities. In particular, those with a history of hypersensitivity to penicillin or cephalosporin drugs may experience severe allergic reactions if this medication is administered. Moreover, patients with genetic disorders that prevent them from breaking down lactose should not use this medication. Patients with a history of gastrointestinal disorders, those with allergic predispositions, individuals with impaired kidney function, elderly patients, or those in poor general condition should use this medication cautiously. Gastrointestinal side effects may include nausea, vomiting, diarrhea, and abdominal pain, and in severe cases, pseudomembranous colitis may occur; thus, if symptoms are severe, medication should be discontinued immediately. Hypersensitivity reactions can manifest as skin rashes, hives, or anaphylactic shock, necessitating caution. Kidney function may be affected, so regular kidney function tests should be performed, and any abnormal symptoms should be reported immediately. Blood abnormalities such as anemia and thrombocytopenia have been reported, hence regular blood tests are recommended. Due to dysbiosis, fungal infections like candidiasis may occur, and if symptoms like stomatitis develop, prompt consultation with a healthcare provider is necessary. If a rash or severe reaction occurs on the skin, the drug should be discontinued and appropriate treatment sought. Symptoms of liver dysfunction may also appear, thus regular liver function tests are advisable. Rarely, neurological side effects such as headaches, seizures, or aseptic meningitis have been reported; any symptoms should be immediately communicated to healthcare professionals. This medication poses a low risk to the fetus during pregnancy but should only be used when essential, and care must be taken during breastfeeding as it may affect the baby. Children, especially newborns or infants under 6 months, have immature kidney function, thus administration should be done cautiously. Elderly patients may have a higher risk of side effects due to decreased physiological functions, thus dosage and intervals need to be adjusted and monitored. There may be drug interactions with this medication, so if other medications are being taken, healthcare providers must be informed. In case of overdose, neurological symptoms and kidney failure may occur, necessitating immediate emergency treatment; if needed, blood dialysis can be utilized to eliminate the drug. For long-term use of this medication, regular liver, kidney, and blood tests should be conducted, and it should only be used for the minimum duration required to prevent the emergence of resistant bacteria. Persistent diarrhea or abdominal pain following antibiotic use may suggest the possibility of pseudomembranous colitis, warranting immediate diagnosis and treatment. Users of this medication should always be vigilant for allergic reactions and other unusual side effects.

Serious side effects

Hives, severe swelling (Quincke edema), chest tightness, difficulty breathing, cold sweat, pallor (severe allergic reaction) Serum sickness-like reactions, anaphylactic shock, anaphylactic shock Severe rash with high fever, blistering, skin peeling, pain of oral/ocular mucosa (severe skin adverse reactions) Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme, exfoliative dermatitis, acute generalized exanthematous pustulosis (AGEP)

Mild side effects

• Nausea
• vomiting
• diarrhea
• loss of appetite
• upper abdominal pain
• abdominal pain
• dyspepsia
• rash
• itching
• headache

This medication should be stored in a tightly sealed container to prevent air exposure, ideally at room temperature between 1 and 30 degrees Celsius. Proper storage can help maintain the drug's efficacy for a longer duration.

Appearance

White oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle, 300 tablets/bottle