Provic Tablet (Clopidogrel Besilate)

Adult dose

○ Adults 1. For patients with ischemic stroke, myocardial infarction, or peripheral arterial disease, administer clopidogrel 75 mg orally once daily. 2. For patients with acute coronary syndrome (unstable angina or non-Q-wave myocardial infarction), start with a loading dose of 300 mg of this medicine once daily on the day treatment is initiated, followed by a maintenance dose of 75 mg orally once daily. Aspirin 75 ～ 325 mg should be coadministered with this medicine once daily. 3. For patients with atrial fibrillation, administer 75 mg of this medicine orally once daily. Aspirin 75 ～ 100 mg should be coadministered with this medicine once daily. ○ Patients with renal impairment : Treatment experience in patients with renal impairment is limited. ○ Patients with hepatic impairment : Treatment experience in patients with moderate hepatic disease and a bleeding diathesis is limited. This medicine may be taken with or without food.

This medication prevents platelets from aggregating, thereby preventing blood clotting. The effect of this drug may be reduced in individuals with genetic deficiencies in a specific enzyme (CYP2C19), so alternative treatment methods should be considered in such cases. Patients with allergies to this drug or its components, those with bleeding disorders, patients with severe liver impairment, and women who are breastfeeding should not take this medication. This drug should be used with caution in patients at high risk of bleeding, and if any bleeding symptoms appear, it is crucial to consult a physician immediately. Patients scheduled for surgery should stop taking this medication 5-7 days prior to the procedure, and caution is also needed if taken alongside other drugs that increase the risk of bleeding. Patients should be aware that bleeding may occur while taking this medication, and should notify medical staff immediately if they experience any bleeding symptoms or adverse reactions. This medication is generally not recommended for use in pregnant women, except in special circumstances, and breastfeeding women should determine the appropriateness of use with their physician. It is recommended not to use this medication in children as safety and effectiveness have not been established. Elderly patients may have a higher risk of bleeding, requiring dose adjustments and careful monitoring. In cases of overdose, the risk of bleeding may increase, and as there is no specific antidote, platelet transfusion may be necessary to stop the bleeding. This drug may interact with other medications, so it is essential to inform the physician or pharmacist of all other medications being taken. Lastly, keep this medication out of the reach of children and do not transfer it to another container.

• Hemorrhage
• gastrointestinal bleeding
• bleeding requiring hospitalization
• purpura
• contusion
• hematoma
• epistaxis
• hematoma
• hematuria
• intraocular bleeding

Store this medication in a tightly sealed container to protect it from air and moisture, and maintain the storage temperature between 1°C and 30°C. This way, the efficacy and safety of the medication can be preserved for a longer duration.

Appearance

Pink round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle