Pencure Semi Tablet

Adult dose

For children aged 12 years and older and adults: The dosage should be adjusted according to the severity of the patient's pain and therapeutic response. It is recommended to administer an initial dose of 4 tablets, followed by a dosing interval of at least 6 hours, but not to exceed 16 tablets per day. Administer the lowest effective dose for the shortest duration possible. Avoid administering this medication for longer than necessary, and in cases where prolonged administration is required due to the characteristics and severity of the disease, regular monitoring should be conducted to assess the continued need for this medication. Elderly Administer the usual adult dose. However, in patients aged 75 years and older, oral tramadol administration may increase the elimination half-life of tramadol by 17%, so the medication should be administered at intervals of at least 6 hours. Renal impairment For patients with moderate renal impairment (creatinine clearance 10-30ml/min), the dosing interval should be extended to 12 hours. Administration is not recommended for patients with severe renal impairment (creatinine clearance less than 10ml/min). Tramadol is cleared very slowly during hemodialysis and filtering; therefore, it is unnecessary to re-administer this medication to maintain analgesic effects after dialysis. Hepatic impairment For patients with moderate hepatic impairment, careful consideration should be given to extending the dosing interval for administration. This medication should not be administered to patients with severe hepatic impairment.

Child dose

For children aged 12 years and older and adults: The dosage should be adjusted according to the severity of the patient's pain and therapeutic response. It is recommended to administer an initial dose of 4 tablets, followed by a dosing interval of at least 6 hours, with a maximum of 16 tablets per day.

This medication should be discussed with a doctor or pharmacist if you regularly consume more than three alcoholic drinks a day, as it may lead to liver damage. If you experience a rash or hypersensitivity reactions while taking this medication, discontinue use and consult a doctor immediately. The ingredients in this medication may increase the risk of seizures, so patients with a history of seizures or risk factors should use this medication with caution. Rarely, serious allergic reactions may occur; if you experience difficulty breathing or severe skin reactions, seek medical attention immediately. For patients with acute and severe asthma, there is a risk of life-threatening respiratory depression following the administration of this medication, so it should be administered in an environment supervised by medical personnel. Taking this medication with alcohol or central nervous system depressants may cause severe drowsiness, respiratory depression, and coma, thus caution is critical when combining. Patients with increased intracranial pressure or head injuries may experience worsened symptoms due to respiratory depression when taking this medication, so use should be approached with caution. This medication can lead to psychological and physical dependence, so long-term use should be closely monitored for signs of dependency. Patients with impaired liver function should consult a doctor before taking this medication and should not take it in conjunction with other acetaminophen products. Patients with certain genetic metabolic characteristics may metabolize this medication quickly, increasing the risk of respiratory depression, thus close monitoring is required. This medication should not be used by children under 12 years old or pediatric patients after specific surgeries, and adolescents over 12 years old should avoid use if risk factors are present. Patients with sleep apnea or hypoxemia may experience worsening symptoms after taking this medication; therefore, ongoing assessment and dosage adjustments are necessary. Elderly patients or those at risk for hyponatremia should be carefully monitored for symptoms of hyponatremia while taking this medication. This medication should not be used in patients with specific past medical conditions or medication histories; it is important to inform a doctor before taking. This medication can cause drowsiness and dizziness, so caution is advised when driving or operating machinery. In case of overdose, serious side effects such as respiratory depression, seizures, or liver damage may occur; therefore, strict adherence to dosing is necessary and immediate medical attention should be sought in emergencies. This medication should be stored in a safe place out of reach of children to prevent misuse and abuse.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, peeling skin, pain in oral/ocular mucous membranes, dyspnea or difficulty breathing, asthma attacks, abnormal respiratory symptoms accompanied by coughing and fever, yellowing of the skin or eyes (jaundice), extreme lethargy, sudden and severe headaches, thunderclap headache, seizures, altered consciousness, visual disturbances, paralysis, urination issues, etc.

Mild side effects

• Decreased appetite
• insomnia
• depression
• dizziness
• headache
• drowsiness
• nausea
• vomiting
• constipation
• dry mouth

This medication should be stored in a tightly sealed container that is well-ventilated, at a temperature between 1 and 30 degrees Celsius. Storing it this way will help maintain its effectiveness for a longer period.

Appearance

Pale yellow rectangular film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle