Diaryl Tablet 4 mg (Glymeperide)

Adult dose

Adjust individually for each patient. Swallow without chewing with more than 1/2 glass of water. This medication is taken orally once a day. It should be taken before breakfast or immediately before the first meal. The initial dose is 1 mg taken once daily, and it can be increased by 1 mg at 1-2 week intervals. Generally, doses above 4 mg yield minimal additional effects, but it can be increased to a maximum of 6 mg or 8 mg if necessary.

This medication should not be used in patients with insulin-dependent diabetes, diabetic ketoacidosis, or coma. Patients who have had an allergic reaction to this medication or to sulfonylureas should not take it. There is no experience with severe liver or kidney dysfunction, and switching to insulin therapy is recommended. Women who are pregnant or nursing should not take this medication, and patients with severe infections, major surgeries, or severe trauma should receive insulin treatment. Care is required when there are gastrointestinal issues, as food absorption may be impaired, increasing the risk of hypoglycemia. This medication is contraindicated in patients with genetic lactose intolerance. During the first week of taking this medication, there is a high risk of hypoglycemia, so blood sugar should be monitored frequently. Particular caution is required for the elderly, patients in poor nutritional status, those who skip meals, individuals with an imbalance between exercise and food intake, people who consume a lot of alcohol, and those with reduced liver or kidney function. Additionally, individuals with other endocrine disorders or those taking multiple medications may also have an increased risk of hypoglycemia. If hypoglycemic symptoms appear, immediate intake of sugar is necessary, and if symptoms are severe, medical personnel should be informed. Taking this medication may cause hypoglycemic symptoms such as headache, hunger, nausea, fatigue, confusion, drowsiness, loss of consciousness, etc. Vision changes, gastrointestinal problems, liver function abnormalities, blood abnormalities, and allergic reactions may also occur; if any unusual symptoms arise, consult a doctor immediately. Severe hypoglycemia or allergic reactions can be life-threatening, requiring prompt treatment. To control blood sugar, this medication should be taken regularly, along with dietary measures and exercise. To prevent hypoglycemia, always carry sugar, and ensure that family members understand the hypoglycemic symptoms and treatment methods. In stressful situations, surgeries, or infections, blood sugar control may become more difficult, so consultation with a physician is necessary. This medication may interact with other drugs, so if you are taking other medications, you must inform your doctor. Particular blood sugar changes may occur when taken with certain antibiotics, antifungals, beta-blockers, and steroids. It is best to avoid use during pregnancy or breastfeeding as it may affect the fetus and newborn. Safety and efficacy have not been established in children under 18 years of age. Elderly patients should be careful with dosage adjustment due to potential decreased kidney function. In cases of overdose, severe hypoglycemia can occur, necessitating immediate emergency treatments such as inducing vomiting, blocking drug absorption, or administering intravenous glucose. Keep out of reach of children and store in the original container to prevent drug misuse and degradation of quality.

Serious side effects

Urticaria, severe swelling, difficulty breathing, hypotension, anaphylaxis, angioedema, Stevens-Johnson syndrome (mucocutaneous reaction syndrome), liver dysfunction (cholestatic disorders, jaundice, hepatitis, hepatic failure), cerebrovascular symptoms similar to severe hypoglycemia, thrombocytopenia, leukopenia, hemolytic anemia, erythropenia, agranulocytosis, pancytopenia, thrombocytopenic purpura, shock.

Mild side effects

• Headache
• severe hunger
• nausea
• vomiting
• fatigue
• sleep disturbances
• anxiety
• aggression
• decreased concentration
• decreased agility

This medication may be sensitive to air or moisture, so it should be stored in a tightly sealed container. It is best to maintain a storage temperature between 1 and 30 degrees Celsius.

Appearance

Light blue rectangular tablets

Package unit

For domestic use: 100 tablets/bottle, 30 tablets/bottle; For export: 100 tablets/bottle, 30 tablets/bottle, 30 tablets (10 tablets/PTPX3)