Dairid Tablet (Glimepiride)

Adult dose

Individual dosage should be adjusted for each patient. Administer orally once daily. It should be taken before breakfast or just before the first meal. The initial dose for monotherapy is to start with glimepiride 1 mg once daily, increasing by 1 mg as needed at intervals of 1-2 weeks. Generally, doses above 4 mg yield little additional effect, but up to 6-8 mg may be increased if needed. If 4 mg per day fails, consideration should be given to switching to insulin therapy.

This medication should not be used in patients with type 1 diabetes or those in a state of diabetic ketoacidosis or coma. It should not be administered to patients with allergies to this drug, its components, or to sulfonylureas and sulfonamide drugs. There is no experience using this medication in patients with severe hepatic or renal impairment, thus switching to insulin therapy is generally recommended. Pregnant or potentially pregnant women, and nursing mothers should not use this medication. In patients with severe infections or those before and after surgery, or after serious trauma, it is advisable to administer insulin therapy. Caution is required in cases of gastrointestinal issues such as diarrhea or vomiting, as there is a risk of hypoglycemia due to poor nutrient absorption. This medication contains lactose, so individuals with lactose intolerance or specific genetic metabolic disorders should not take it. During the first week of treatment, the risk of hypoglycemia is high, so careful monitoring of blood glucose is necessary. Particularly in the elderly, patients who have difficulty cooperating, those with poor nutritional status, those who have irregular eating habits, and those whose exercise and carbohydrate intake are not balanced, caution should be exercised. Patients who consume alcohol frequently or skip meals and those with impaired renal or liver function may also have an increased risk of hypoglycemia. Caution is also required in patients with other endocrine disorders, those who overdose on medication, and those taking multiple medications. This medication contains yellow coloring agents, so individuals allergic to this ingredient should use it cautiously. When taking this medication, one should be well aware of hypoglycemia symptoms, and if symptoms occur, they should immediately consume sugars to manage their blood sugar levels. Symptoms of hypoglycemia can include headaches, severe hunger, nausea, vomiting, fatigue, sleep disturbances, anxiety, aggression, decreased concentration, reduced agility or activity, depression, confusion, speech disturbances, aphasia, visual disturbances, tremors, partial paralysis, sensory alterations, dizziness, weakness, loss of self-control, temporary mental confusion, drowsiness, bradycardia, sweating, cold clammy skin, tachycardia, hypertension, palpitations, angina, cardiac arrhythmia, blurred vision, upper abdominal fullness or pressure. Severe cases may lead to loss of consciousness or seizures, thus immediate medical assistance is required. Moreover, gastrointestinal disturbances, liver function abnormalities, reduced blood cell count, and allergic reactions may occasionally occur, so any unusual symptoms should be reported to a doctor immediately. This medication should be combined with dietary therapy and exercise for effective blood glucose control, and it is important to take it regularly. When receiving treatment at another hospital while taking this medication, always inform the healthcare provider about the diabetes condition and medication usage. In stress situations such as surgery, infections, or trauma, a temporary switch to insulin therapy may be necessary. Dosage should begin at a low level, and effects should be confirmed through blood sugar and urine tests, adjusting as necessary. At the beginning of treatment or when changing medications, careful attention is required as hypoglycemia or hyperglycemia symptoms may affect driving or operating machinery. This medication is metabolized in the liver, so caution is needed regarding interactions when taken with other drugs that affect liver metabolism. Concurrent use with drugs that enhance the hypoglycemic effect may increase the risk of hypoglycemia. Conversely, using drugs that reduce the hypoglycemic effect may make glycemic control difficult. Certain medications like beta-blockers may obscure hypoglycemia symptoms, so caution is advised. Alcohol consumption can also affect blood sugar control, so careful attention should be paid. In cases of overdose, severe hypoglycemia can occur, requiring immediate emergency measures such as inducing vomiting, blocking drug absorption, or administering glucose injections. After excessive dosing, the patient's condition should be closely monitored for at least 24-48 hours. This medication should be kept out of the reach of children, stored tightly sealed in its original container. Pregnant or nursing women should abstain from taking this medication, and those planning a pregnancy should consult a doctor. Safety and efficacy for children under 18 have not been established, so it is best not to use it for this population. The elderly may experience reduced renal function, so dosing should be adjusted and monitored carefully.

Serious side effects

Hives, severe swelling (edema), tightness in the chest, difficulty breathing, cold sweats, pallor, severe rash with fever, blisters, skin peeling, pain in the mouth/eye mucosa, wheezing or breathlessness, asthma attacks, respiratory distress accompanied by cough and fever, yellowing of the skin or eyes (jaundice), extreme lethargy, sudden and severe headaches, thunderclap headaches, seizures, confusion of consciousness, visual disturbances, paralysis, urination changes.

Mild side effects

• Headaches
• severe hunger
• nausea
• vomiting
• fatigue
• sleep disturbances
• anxiety
• aggression
• decreased concentration
• reduced agility or activity

This medication should be stored in a tightly sealed container to protect it from air and light, at a temperature of 1 to 30 degrees Celsius. Storing it this way will help maintain its effectiveness.

Appearance

Green rectangular tablet

Package unit

30 tablets/bottle, 100 tablets/bottle