Nutrihex Injection

Adult dosage

Administered intravenously as a continuous drip at a maximum dosage of 1–1.5 g of total amino acids per kg of body weight per day. The infusion rate is ideally set to deliver approximately 10 g of total amino acids over 60 minutes, meaning approximately 30-40 drops per minute. However, the maximum daily dose of D-Sorbitol is set at 100 g.

Children's dosage

In children, dosage and injection rates should be adjusted accordingly.

This medication must only be used according to a physician's instructions. It should not be administered to patients with hepatic coma or at risk of it, severe renal dysfunction, and patients who have difficulty utilizing nitrogen due to metabolic disorders. Patients with congestive heart failure, pulmonary edema, oliguria, anuria, lactic acidosis, methyl alcohol poisoning, hypernatremia, hereditary fructose intolerance, and heart-related diseases should also not use this medication. Careful administration is required for patients with severe acidosis, congestive heart failure, edema due to sodium retention, hyperkalemia, liver dysfunction, renal dysfunction, or diabetes insipidus, and their condition should be monitored closely. Although rare, hypersensitivity reactions such as skin rashes may occur while using this medication; if such symptoms appear, administration should be discontinued. Gastrointestinal symptoms such as nausea or vomiting may occasionally appear. Symptoms related to the heart, including chest discomfort, palpitations, rapid heartbeat, and increased blood pressure, may arise. Rapid administration in large volumes can lead to acidosis, liver dysfunction, and renal dysfunction, so caution is needed. Chills, fever, headache, vascular pain, respiratory distress, and in severe cases, respiratory arrest, shock, bronchospasm, and urinary tract spasms may occur. Complications such as metabolic acidosis, hypophosphatemia, alkalosis, hyperglycemia, diabetes, dehydration, rebound hypoglycemia, elevated liver enzymes, vitamin imbalances, and electrolyte imbalances, as well as hyperammonemia in pediatric patients, may also arise. Patients with impaired liver or renal function may experience elevated blood urea nitrogen levels, so caution is required. When administering large dosages or in conjunction with other solutions containing electrolytes, electrolyte balance must be maintained. The administration rate should be slow, as rapid infusion may lead to chills or vomiting and can worsen amino acid loss through the kidneys. This medication must be prepared and managed in a sterile state, and the injection apparatus should also be kept sterile to reduce the risk of infection. If the solution is cloudy or abnormal, it should not be used, and if the packaging is damaged or the outlet film is torn, it should also not be used. The safety of this medication in pregnant women has not been established; it should only be used when absolutely necessary, and the benefit of treatment must outweigh the risks. For children, due to potential immaturity of liver function, dosing concentrations should be lower, and blood ammonia levels should be monitored frequently. Elderly patients may have diminished physical function, so the administration rate should be slow, and dosing should be adjusted. Using this medication concurrently with tetracycline antibiotics may reduce the protein-sparing effect.

Serious side effects

• Rash
• chest tightness
• respiratory distress
• respiratory arrest
• shock
• bronchospasm
• pulmonary edema
• oliguria
• anuria
• liver failure

Mild side effects

• Nausea
• vomiting
• rash
• chest discomfort
• palpitations
• rapid heartbeat (tachycardia)
• increased blood pressure
• chills
• fever
• headache

This medication should be stored in a sealed container to prevent exposure to air. Maintaining a storage temperature between 1 degree and 30 degrees Celsius is important. This will help preserve the effectiveness and safety of the medication for a long time.

Appearance

A colorless or light yellow transparent solution filled in a colorless transparent glass container or polypropylene aqueous injection vial.

Package unit

100mL/bottle, 250mL/bottle, 250mL/bag