Clothin Tablets 500 mg (Clarithromycin)

Adult dosage

Adults The usual dose of clarithromycin is 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The usual duration of treatment is 7～14 days. In patients with renal impairment and a creatinine clearance of 30mL/min or less, the dose should be reduced by half. That is, administer 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer this medicine to these patients for more than 14 days. Mycobacterial infections Administer 500mg (potency) of this medicine twice daily. In this case, it should be administered concomitantly with other antimycobacterial agents, such as ethambutol, clofazimine, and rifampin. Eradication of Helicobacter pylori in patients with duodenal ulcers Administer 500mg (potency) of this medicine three times daily with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for an additional 14 days. That is, administer clarithromycin 500mg (potency) three times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Children's dosage

Children 12 years of age and older: Same as adults For children under 12 years of age, use clarithromycin dry syrup.

This drug should not be administered to certain patients. For example, patients allergic to its ingredients or additives, patients with severe heart disease or liver failure, and those with severe renal impairment should avoid taking this medicine. Moreover, it is safer for pregnant or breastfeeding women and patients with central nervous system infections not to use this medicine. This drug can interact with other medications, and serious side effects may occur when used in combination with certain drugs, so caution is required. Patients taking medications that may affect the heart, liver, or kidney function should consult a physician. When administering this drug, it should be used with caution in patients with liver disease, renal failure, heart disease, elderly patients, or those taking other antibiotics. If any allergic reactions or drug hypersensitivity are suspected, administration should be stopped immediately, and appropriate treatment should be sought. This drug can cause various adverse reactions. Occasionally, allergic reactions such as skin rash, itching, or hives may occur, and gastrointestinal symptoms may include nausea, vomiting, diarrhea, and abdominal pain. Rare side effects reported include liver dysfunction, renal impairment, central nervous system abnormal symptoms, and cardiac arrhythmia, so if any abnormal symptoms appear, notify the medical personnel immediately. It is important to take this drug only as long as necessary to prevent the occurrence of resistant bacteria, as prolonged use may lead to resistance. Furthermore, if gastrointestinal symptoms like diarrhea persist, serious complications such as pseudomembranous colitis may occur, so immediate consultation with medical personnel is required. This drug has potential interactions with many other medications; therefore, if you are currently taking any medications, you must inform your physician and follow their instructions for use. In particular, when taken with anticoagulants, cardiac medications, anticonvulsants, immunosuppressants, and some sedatives, blood concentration changes should be monitored. If pregnant or breastfeeding, it is safest not to take this medicine; if it must be taken, it should be done in consultation with a physician, and breastfeeding should be suspended. In children or the elderly, caution should be exercised with dosing, especially in elderly patients whose liver or kidney function may be impaired, as dosage adjustments may be necessary. In cases of overdose, gastrointestinal symptoms or central nervous system abnormalities may occur; therefore, immediate medical attention should be sought for appropriate treatment. This medicine should not be refrigerated when stored; it should be kept in a sealed container away from direct sunlight at room temperature.

Shock, anaphylactic symptoms, dyspnea, convulsions, flushing, rash, itching, urticaria, skin redness, angioedema, joint swelling, drug eruption, abdominal bloating, nausea, vomiting, dyspepsia, abdominal pain, malaise, flatulence, diarrhea, oral mucosal erosion, epigastric pain, thirst, tooth discoloration, pancreatitis, increased amylase, taste disturbance, decreased appetite, constipation, stool discoloration, pseudomembranous colitis, hemorrhagic colitis, fever, cough, dyspnea, abnormal chest X-ray, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, exacerbation of acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, derealization, convulsions, tremors, numbness, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, elevated serum creatinine, increased BUN, interstitial nephritis, renal failure, rhabdomyolysis, myalgia, weakness, elevated CPK, increased serum myoglobin, increased urinary myoglobin, stomatitis, mucositis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, lethargy, headache, taste disorder, hearing loss, paresthesia, arthralgia, myalgia, olfactory disturbance, hypoglycemia, tinnitus, hearing impairment, purpuric rash, acute generalized exanthematous pustulosis (AGEP), muscle cramps, musculoskeletal rigidity, myopathy, elevated blood urea nitrogen, injection site phlebitis, injection site pain, injection site inflammation, fever, asthenia, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, increased serum lactate dehydrogenase, increased international normalization ratio, prolonged prothrombin time, abnormal urine color, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, abdominal distension, tongue discoloration, tooth discoloration

This drug should be stored in a tightly sealed container to protect it from air and moisture. Additionally, it is important to keep it away from direct sunlight and in a dry place. The storage temperature should be maintained between 15 to 30 degrees Celsius.

Appearance

Yellow, oblong film-coated tablet

Package unit

100 tablets per bottle, 30 tablets per bottle