Plavix Tablet (Clopidogrel Hydrogen Sulfate)

Adult dose

○ Adults 1. In patients with ischemic stroke, myocardial infarction, or peripheral arterial disease, administer clopidogrel 75 mg orally once daily. 2. In patients with acute coronary syndrome (unstable angina or non-Q-wave myocardial infarction), start treatment on the first day with a loading dose of 300 mg once daily, followed by an oral maintenance dose of 75 mg once daily. Aspirin 75 ～ 325 mg must be administered concomitantly with this medicine once daily. 3. In patients with atrial fibrillation, administer this medicine 75 mg orally once daily. Aspirin 75 ～ 100 mg must be administered concomitantly with this medicine once daily. ○ Patients with renal impairment : Treatment experience in patients with renal impairment is limited. ○ Patients with hepatic impairment : Treatment experience in patients with moderate liver disease who have a bleeding diathesis is limited. This medicine may be administered with or without food.

This medication helps prevent platelets from clumping together, thus aiding the smooth flow of blood. First, individuals who genetically have reduced functional activity of the enzyme CYP2C19 may find this medication ineffective. In such cases, alternative treatments should be considered. Additionally, concomitant use of medications that activate this enzyme can increase the concentration of this medication too high, raising the risk of bleeding, so it is advisable not to use them together. This medication should not be used in patients with allergies to certain components, severe bleeding, very poor liver function, nursing women, and patients with lactose intolerance or specific genetic metabolic disorders. Patients at risk of bleeding, those with blood disorders, and those scheduled for surgery should use this medication with caution and notify healthcare providers immediately if any bleeding symptoms occur. Particularly, increased care is necessary when taken with other medications that may raise the risk of bleeding. During the use of this medication, bleeding times may be prolonged; hence, if bleeding doesn’t stop or the bleeding site worsens, it is necessary to consult a doctor immediately. This medication can rarely cause thrombocytopenia or serious blood disorders, thus patients should inform healthcare providers if symptoms of fever or infection occur. Side effects may include abdominal pain, indigestion, diarrhea, rash, etc., and if serious side effects occur, immediate medical attention is required. If pregnant or nursing, this medication may affect the fetus or infant, so it is essential to consult a physician. Elderly patients or those with impaired kidney or liver function may have increased sensitivity to the effects and side effects of this medication, requiring caution during administration. In cases of overdose, the risk of bleeding may increase, and since there is no specific antidote, treatment such as platelet transfusion may be necessary for severe bleeding. This medication has not been established for safety and efficacy in children, so it is advisable not to use it. Finally, if starting any new medications or undergoing surgery while taking this medication, be sure to inform healthcare providers.

• hemorrhage
• gastrointestinal hemorrhage
• purpura
• contusion
• hematoma
• epistaxis
• hematuria
• intraocular hemorrhage
• intracranial hemorrhage
• neutropenia

This medication should be stored in a tightly sealed container to avoid exposure to air or moisture, at a temperature between 1°C and 30°C. Storing it this way helps maintain its effectiveness for a longer period.

Appearance

Pink round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle, 300 tablets/bottle