Hurofix Tablets (Clopidogrel Hydrogen Sulfate)

Adult dose

○ Adults 1. For patients with ischemic stroke, myocardial infarction, or peripheral arterial disease, administer 75 mg of clopidogrel orally once daily. 2. For patients with acute coronary syndrome (unstable angina or non-Q-wave myocardial infarction), start with a loading dose of 300 mg of this medicine once daily on the day treatment is initiated, followed by a maintenance dose of 75 mg orally once daily. In this case, aspirin 75 ～ 325 mg should be administered once daily in combination with this medicine. 3. For patients with atrial fibrillation, administer 75 mg of this medicine orally once daily. In this case, aspirin 75 ～ 100 mg should be administered once daily in combination with this medicine. ○ Patients with renal impairment : Treatment experience in patients with renal impairment is limited. ○ Patients with hepatic impairment : Treatment experience in patients with moderate liver disease with a bleeding diathesis is limited. This medicine may be administered with or without food.

This medication helps prevent platelets from aggregating and allows blood to flow smoothly. This medication may be less effective in individuals with genetically reduced function of a specific enzyme, CYP2C19, so alternative treatments should be considered in such cases. Moreover, co-administration of this drug with medications that activate CYP2C19 may increase drug concentration and raise the risk of bleeding, so concurrent use should be avoided. This medication should not be used in patients with bleeding issues, severely damaged liver, nursing women, or individuals with specific genetic disorders. Patients at high risk of bleeding or those scheduled for surgery should either discontinue this medication or use it cautiously under medical supervision. This medication can prolong bleeding time, making even minor wounds bleed longer; thus, if bleeding does not stop or if there are unusual symptoms, it is essential to notify a doctor immediately. When taking this medication, caution should be exercised as the risk of bleeding may increase if used with aspirin or other drugs that affect blood coagulation. It is important to regularly check for bleeding or blood-related adverse reactions through blood tests or other examinations. This drug can rarely cause a serious blood disorder known as Thrombotic Thrombocytopenic Purpura (TTP), so if sudden bleeding, symptoms of anemia, or neurological abnormalities occur, visit a hospital immediately. Side effects such as headache, dizziness, dyspepsia, diarrhea, and rash may occur during treatment; however, most are mild, and serious symptoms should be discussed with a doctor. During pregnancy, the effects on the fetus are not clear; however, in emergency situations like myocardial infarction or stroke, treatment should not be delayed, and to reduce bleeding risk, administration should be stopped before delivery. In the case of nursing mothers, it is uncertain whether this medication is excreted in breast milk, so a discussion with a doctor is essential regarding whether to continue breastfeeding or discontinue medication. Elderly patients or those with reduced kidney function may have a higher risk of bleeding; thus, dosage adjustment and monitoring of conditions are necessary. Overdosage may increase the risk of bleeding, so the prescribed dosage must be strictly followed, and if bleeding is severe, measures such as platelet transfusion may be necessary. This medication should be kept out of reach of children, and care must be taken not to transfer it to another container as this may alter its quality.

• Hemorrhage
• gastrointestinal bleeding
• purpura
• contusion
• hematoma
• epistaxis
• hematoma
• hematuria
• intraocular hemorrhage
• intracranial hemorrhage

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. The storage temperature should be between 1 to 30 degrees Celsius (room temperature) to safely maintain the efficacy of the medication.

Appearance

Pink, round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle