Rivotril Tablets (Clonazepam)

Adult dose

The dose should be adjusted individually according to the patient's clinical response and tolerability. ○ Epilepsy and partial-onset (focal) seizures, primary and secondarily generalized tonic-clonic seizures (grand mal), and epilepsy in infants and children (particularly typical and atypical absence seizures) Initial dose - To prevent adverse effects from occurring early in treatment, increase the dose slowly until the patient's optimal dose is determined, reaching the maintenance dose within 2-4 weeks. Maintenance dose - The dose should be adjusted appropriately according to the patient's age and symptoms (including seizure duration, frequency and severity, and whether other antiepileptic drugs are used concomitantly). Determine the optimal dose considering tolerability and clinical response to this medication. 1. Adults: The initial dose of clonazepam should not exceed 1.5㎎ daily and should be administered orally in 3 divided doses. If the doses are not equal, administer the largest dose in the evening. Increase the dose by 0.5㎎ every 3 days to a maintenance dose of 3-6㎎ daily. Once the maintenance dose is reached, administer once daily. ○ Panic disorder 1. Adults: The initial dose is 0.5mg daily in 2 divided doses. In most patients, the dose may be increased to the target dose of 1mg daily after 3 days. The recommended dose of 1mg daily is based on the optimal efficacy observed in fixed-dose studies. However, if necessary, the dose may be increased by 0.25~0.5mg every 3 days, up to a maximum of 4mg daily in 2 divided doses, until panic disorder is controlled or adverse effects prevent further increases. To reduce drowsiness, the total daily dose may be taken as a single dose at bedtime. At the end of treatment, gradually reduce the dose by 0.25mg every 3 days. ○ Older adults Administer the lowest possible dose to older adults, and use particular caution when increasing the dose.

Child dose

2. Children (10-16 years): The initial dose is 1-1.5㎎ daily in 2-3 divided doses. Increase the dose by 0.25-0.5㎎ every 3 days to a maintenance dose of 3-6㎎ daily. 3. Infants and children (10 years or younger or weighing 30㎏ or less): The initial dose is 0.01-0.03㎎ per ㎏ of body weight daily in 2-3 divided doses. Increase the dose by 0.25-0.5㎎ every 3 days to a maintenance dose of 0.1㎎ per ㎏ of body weight daily. The maximum dose is 0.2㎎ per ㎏ of body weight.

This medication may increase the risk of suicidal thoughts or behaviors, so any changes in mood or unusual behaviors during treatment should be reported to healthcare professionals immediately. Taking this medication with alcohol or other central nervous system depressants can cause severe drowsiness, respiratory depression, and cardiac function deterioration, so concomitant use should be avoided. Using it with narcotics can lead to serious side effects such as respiratory depression or coma, so it must be used strictly according to a doctor's instructions. This medication should not be taken by patients with acute narrow-angle glaucoma, severe myasthenia gravis, drug dependence, severe liver disease, or respiratory failure. Patients with heart, kidney, or brain diseases, as well as the elderly, frail patients, or those with impaired respiratory function should use this drug cautiously. Long-term use may lead to dependence, and sudden discontinuation may cause withdrawal symptoms; therefore, it should be tapered off gradually under a doctor's supervision. Drowsiness, dizziness, and motor disturbances may occur at the beginning of treatment, so caution should be taken when driving or operating dangerous machinery. Pregnant women or those who may become pregnant should consult healthcare professionals, as this medication may affect the fetus. For breastfeeding women, the medication can be transmitted through breast milk to the baby, so breastfeeding should be stopped or discussed with a doctor. This drug can interact with other antiepileptic drugs or numerous medications, so it's important to inform your healthcare professional of any other medications you are taking. In case of overdose, symptoms such as severe drowsiness, coma, and respiratory depression may occur, requiring immediate emergency treatment and appropriate action under a doctor's supervision. This medication is sensitive to light and moisture, so it should be stored in its original container and kept out of the reach of children.

suicidal thoughts, suicidal behavior, depression, abnormal changes in mood and behavior, severe sedation, respiratory depression, coma, drowsiness, staggering, dizziness, headache, malaise, ataxia, irritability, lethargy, mood instability, muscle hypotonia, headache, heaviness of the head, insomnia, decreased attention, stupor, tremor, numbness, excessive movement, abnormal behavior, gait abnormalities, anxiety, hallucinations, muscle hypertonia, delirium, chorea, inability to perform antagonistic movements, unilateral weakness, agitation, aggressive behavior, attention deficit, delayed response, anterograde amnesia, confusion, sweating, myalgia, hypersensitivity, restlessness, tension, fidgeting, seizures, sweating, muscle and abdominal cramps, sensory disturbances, nonsense, convulsions, loss of reality, depersonalization, auditory hypersensitivity, numbness, limb pain, hypersensitivity to light, sound, and touch, vasogenic edema, dyspnea, blood congestion in the chest, wheezing, sleep-related hyperpnea episodes, respiratory distress, excessive airway secretions, increased sputum, cough, pharyngeal edema, chest pain, diplopia, blurred vision, glare, nystagmus, urinary incontinence, increased salivation, decreased appetite, nausea, vomiting, swallowing difficulties, stomatitis, upper abdominal symptoms, abdominal pain, constipation, diarrhea, hiccups, increased appetite, polydipsia, nocturia, urinary incontinence, dysuria, leukopenia, anemia, thrombocytopenia, eosinophilia, hepatomegaly, elevated AST, elevated ALT, elevated ALP, elevated LDH, elevated γ-GTP, urticaria, itching, skin rash, transient hair loss, pigmentation changes, hirsutism, rash, ankle and facial swelling, weakness, fatigue, weight loss, tiredness, excitement, sensation of heat, facial flushing, fever, weight gain, snoring, irregular menstruation, decreased libido, impotence, lymphadenopathy, allergic reactions, anaphylactic reactions, reversible development of secondary sexual characteristics in children, decreased concentration, restlessness, disorientation, excitability, irritability, aggressive behavior, agitation, hostility, anxiety, sleep disturbances, nightmares, vivid dreams, decreased libido, drowsiness, slow reaction, muscle hypotonia, dizziness, inability to perform coordinated movements, headache, speech difficulties, decreased motor coordination, gait disturbances, anterograde amnesia, visual impairment, cardiac arrest, heart failure, nausea, upper abdominal symptoms, muscle weakness, urinary incontinence, erectile dysfunction, fatigue, falls, fractures, decreased platelet count, delirium, cholestatic hepatitis, memory disturbances, emotional instability, confusion, decreased intellectual capacity, abnormal cooperation, speech difficulties, upper respiratory infections, sinusitis, rhinitis, cough, pharyngitis, bronchitis, constipation, decreased appetite, abdominal pain, allergic reactions, myalgia, influenza, frequent urination, urinary tract infections, blurred vision, dysmenorrhea, vaginitis, delayed ejaculation, erectile dysfunction, cholestatic hepatitis, delirium, drowsiness, depression, dizziness, irritability, ataxia, decreased intellectual capacity, depression, memory disturbances, irritability, decreased intellectual capacity, emotional instability, decreased libido, confusion

This medication should be stored in a tightly closed container that protects it from light, and it is best to keep it at room temperature between 1°C and 30°C. This way, the effectiveness of the medication can be maintained for a long time.

Appearance

Pale orange round tablet

Package unit

100 tablets per bottle