Losanin Plus F Tablets

Adult dose

The usual dose is 1 tablet of Losartan Potassium 50 mg/Hydrochlorothiazide 12.5 mg once daily. Doses exceeding Losartan Potassium 100 mg/Hydrochlorothiazide 25 mg per day are not advisable. As a substitute therapy, patients may be transitioned to this medication from separately adjusted doses of Losartan Potassium and Hydrochlorothiazide. For patients whose blood pressure is not controlled with single therapy using Losartan or Hydrochlorothiazide:

Child dose

There is no experience in using this medication in children and adolescents (under 18 years), therefore it should not be administered.

This medication may cause serious harm to the fetus if taken during pregnancy, especially in the second and third trimesters; therefore, it should be discontinued immediately if pregnancy is confirmed. Patients who are allergic to this medication or have certain kidney dysfunction, liver disease, or electrolyte imbalances should not take it. Patients with specific conditions such as hypotension, kidney problems, liver disease, diabetes, gout, the elderly, etc., need to use this medication with caution. Various side effects such as dizziness, drowsiness, skin rash, cough, and dyspepsia may occur during use, so consult a doctor if any unusual symptoms arise. This medication may affect potassium levels, so caution is advised against taking potassium supplements or potassium-containing medications at the same time. Additionally, grapefruit juice may reduce its efficacy, so it is best to avoid consuming grapefruit juice. As this medication acts to lower blood pressure, dizziness or symptoms of hypotension may occur when beginning treatment or changing the dosage, so caution is required. Women who are pregnant or planning to become pregnant must consult a physician, and those who are breastfeeding should also consult a healthcare professional before taking this medication. This medication is not recommended for children and adolescents, and elderly patients should be carefully monitored due to a higher likelihood of side effects. It is important to regularly monitor kidney function and electrolyte status through blood tests while using this medication. Finally, this medication should be kept out of reach of children and stored in its original container for safety.

Serious side effects

Hives, severe swelling (edema), angioedema (swelling of the larynx/glottis causing airway obstruction, swelling of the face/lips/pharynx/tongue), chest tightness, difficulty breathing, respiratory distress, acute respiratory distress syndrome (ARDS), dry cough, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, oral/ocular mucosal pain, mucosal epidermal syndrome (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell syndrome)

Mild side effects

• General: Abdominal pain, weakness/fatigue, diarrhea, nausea, headache, malaise, fever, orthostatic hypotension, fainting
• Cardiovascular: Palpitations, angina, arrhythmias (atrial fibrillation, sinus bradycardia, tachycardia, ventricular tachycardia, ventricular fibrillation), hypotension, myocardial infarction, secondary heart block
• Gastrointestinal: Appetite loss, constipation, toothache, dry mouth, dyspepsia, flatulence, gastritis, vomiting, nausea, pharyngitis
• Musculoskeletal: Back pain, arm pain, joint pain, arthritis, fibromyalgia, hip pain

This medication should be stored in a tightly sealed container that protects it from light, at room temperature between 1 to 30 degrees Celsius. Storing it this way will help maintain the medication’s efficacy for a long time.

Appearance

Pale yellow oval film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle, 30 tablets/PTP (for export)