Glyrep (Metformin Hydrochloride)

Adult dose

500 mg of Metformin Hydrochloride sustained-release tablet should be administered once daily with the evening meal. After one week, check blood sugar levels and adjust the dosage; the maximum dose is 2000 mg per day. When increasing the dosage, it should be increased by 500 mg weekly until a maximum of 2000 mg is reached, administered with the evening meal. If blood sugar control is not achieved, consider 1000 mg twice daily with meals. In patients with renal impairment, administer once daily.

This medication can rarely cause a serious side effect called lactic acidosis, so it is important to be aware of this condition. Lactic acidosis is a state that occurs when lactic acid builds up excessively in the body and can be very dangerous. Caution is needed when this medication is used in conjunction with other diabetes medications like insulin or sulfonylureas, as severe hypoglycemia can occur. This medication should not be used in patients with moderate to severe renal impairment or in acute conditions such as dehydration, severe infections, heart failure, or acute myocardial infarction. Additionally, it should be temporarily discontinued if iodinated contrast agents are used for radiologic examinations. It is not administered to patients with hypersensitivity to this drug, patients with type 1 diabetes, or patients with a history of lactic acidosis or ketoacidosis. During severe infections, trauma, or surgical procedures, this medication should be temporarily discontinued and restarted once the patient's condition stabilizes. Caution should also be exercised in patients with poor nutritional status, liver function abnormalities, respiratory failure, or excessive alcohol consumption. Kidney function should be monitored regularly while on this medication, and it should be discontinued if renal function declines. Hypoglycemia symptoms may occur, particularly if taken with other hypoglycemic agents or when food intake is insufficient. Gastrointestinal disturbances such as nausea, vomiting, and diarrhea may occur during use, but these symptoms typically improve with time and gradual dosage increases. This medication can cross the placenta during pregnancy, so it should be used with caution and under a healthcare provider's supervision during this time. It is not recommended during breastfeeding. Elderly patients may have an increased risk of kidney function decline, so dosage adjustment and regular renal function monitoring are necessary. There may be interactions with other medications; thus, patients must inform their physician or pharmacist about any other medications they are taking. This medication should be swallowed whole and not chewed or crushed; the tablet coating may pass through in the stool, which is a normal occurrence. Patients should avoid excessive alcohol consumption while taking this medication, and their blood sugar and renal function should be monitored regularly.

Serious side effects

Lactic acidosis (severe metabolic abnormal reaction), urticaria (severe allergic reaction), severe edema (possibly associated with renal dysfunction), hypoglycemia (risk of severe hypoglycemia)

Mild side effects

• Vitamin B12 deficiency
• taste disturbance
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• erythema
• itching
• urticaria

This medication should be stored in a tightly closed container to protect it from air and moisture, ideally at a cool temperature below 25 degrees Celsius. This will help maintain the effectiveness of the medication for a longer period.

Appearance

White to light yellow oblong tablet

Package unit

30 tablets/bottle, 300 tablets/bottle