Glavis Extended Release Tablet 500mg (Metformin Hydrochloride)

Adult dose

The typical initial dose is 500mg of Metformin Hydrochloride extended release tablet taken once daily with the evening meal. The dosage is determined based on individual drug effectiveness and tolerability, and it can be increased to a maximum daily dose of 2000mg. Dosage increases should be made by 500mg weekly, and it can be taken with the evening meal up to a maximum of 2000mg once daily. If blood sugar control is inadequate, consider 1000mg taken twice daily (both with meals).

This medication can rarely cause a serious condition known as lactic acidosis, which can be life-threatening, so caution is needed. If taken with other diabetes medications, hypoglycemia may occur, so be careful. It should not be used in patients with moderate or severe renal insufficiency, dehydration, severe infections, or acute heart disease. This medication should be discontinued before examinations using radiographic contrast agents and can be resumed after confirming normal renal function post-examination. Patients with allergies to the components of this medication, those with type 1 diabetes, or a history of lactic acidosis or ketoacidosis should not take it. In cases of severe infections, major trauma, or pre- and post-surgery, this medication should temporarily be discontinued and resumed after recovery. Patients with poor nutritional status, liver dysfunction, excessive alcohol consumption, dehydration, diarrhea, or vomiting should also exercise caution. In pregnancy, avoid use if there is a risk of placental insufficiency or preeclampsia. While taking this medication, irregular meals, vigorous exercise, or taking interacting medications can increase the risk of lactic acidosis and hypoglycemia, so caution is essential. Side effects may include vitamin B12 deficiency, altered taste sensation, nausea, vomiting, diarrhea, abdominal pain, and loss of appetite, particularly gastrointestinal symptoms that commonly occur early in treatment but usually improve over time. If severe skin rashes or itching occur, discontinue use immediately and consult a physician. Kidney function should be regularly monitored to prevent drug accumulation and risk, especially in the elderly or those with diminished renal function. Alcohol can increase the risk of side effects from this medication, so excessive drinking should be avoided. This medication can be used during pregnancy, but careful observation of fetal growth is required, and it is not recommended while breastfeeding. Safety in pediatric patients has not been established, so it is not to be used in those under 17 years of age. While rare, overdose can lead to hypoglycemia and a risk of lactic acidosis, so immediate medical treatment is necessary in suspected cases. This medication should not be chewed or crushed but swallowed whole; the tablet coating may pass in stool, which is normal. There may be interactions with other medications, so if you are taking any other medications, be sure to inform your doctor or pharmacist. Finally, it is important to regularly monitor blood glucose, renal function, and vitamin B12 levels while taking this medication, and to consistently manage meals and exercise in conjunction with medication use.

Serious side effects

• Lactic acidosis
• hives
• chest tightness
• difficulty breathing
• severe swelling (edema)

Mild side effects

• Vitamin B12 deficiency
• taste disturbance
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• erythema
• itching
• hives

This medication should be stored in a tightly closed container to prevent exposure to air, and it should be kept in a cool place at or below 25 degrees Celsius to maintain its effectiveness.

Appearance

White to pale yellow elongated tablets

Package unit

30 tablets/bottle, 300 tablets/bottle