Bonviva Tablet 150 mg (Ibandronic Acid Sodium Hydrate)

Adult dose

Take 1 tablet once a month regularly in the morning at least 1 hour before consuming food, drinks (excluding water), or other oral medications or dietary supplements (including calcium), with sufficient water. This medication should be swallowed while standing or sitting upright with a sufficient amount (180-240mL) of water, and lying down is prohibited for 60 minutes after taking it. Mineral water may reduce the absorption of this drug.

This medication should not be used in patients who have an allergic reaction to this drug or its other components. Furthermore, it should not be administered to patients with untreated hypocalcemia. Patients should remain in an upright position or sit for at least 60 minutes after taking this medication, and it is not suitable for patients who find it difficult to do so. Patients with esophageal dysfunction where food goes down poorly could be at risk when taking this drug. Since this medication contains lactose, patients with lactose intolerance or related genetic conditions should not take it. Caution is advised when administering this drug to patients with severe renal impairment, requiring medical judgment. Various side effects may occur during the use of this drug, including dyspepsia, nausea, abdominal pain, diarrhea, headache, muscle pain, joint pain, and rash. Flu-like symptoms such as fever, chills, and muscle aches may occur, especially at the beginning of treatment, but are usually temporary. Rarely, symptoms such as esophagitis, esophageal ulcers, dizziness, and low back pain may appear; if severe symptoms arise, it is advisable to consult with a healthcare provider. This drug can cause severe side effects such as inflammation of the eyes or jaw osteonecrosis, hence reporting any unusual symptoms immediately is crucial. If dental treatment is required, an oral examination should be conducted before use, and excessive dental treatment during the course of treatment is recommended to be avoided. This drug may interfere with absorption when taken with food or products containing calcium, magnesium, iron, etc., so it is recommended not to consume any other food or medication for at least 1 hour after taking it. Pregnant or breastfeeding women should avoid using this drug for safety. Older adults can use it without dosage adjustment, but safety and efficacy have not been established in children. Overdose may result in gastrointestinal disturbances or hypocalcemia, necessitating the maintenance of a standing position and immediate visit to a medical institution without inducing vomiting. This drug should be stored out of reach of children, and unused medication should be disposed of properly to prevent environmental contamination.

Serious side effects

Hives, severe swelling (angioedema, facial swelling), severe allergic reactions (including anaphylaxis reaction/shock), severe skin reactions (including Stevens-Johnson syndrome, erythema multiforme, vesicular dermatitis), esophagitis including ulcers or strictures, uveitis, episcleritis and other inflammation of the eye, jaw osteonecrosis, external auditory canal osteonecrosis, atypical femoral fractures, atypical fractures of the ulnar and tibial bones

Mild side effects

• Dyspepsia
• nausea
• abdominal pain
• diarrhea
• bloating
• gastroesophageal reflux disease
• headache
• flu-like illness
• fatigue
• muscle pain

This medication should be kept in a tightly sealed container to prevent exposure to air or moisture and stored at room temperature between 1 to 30 degrees Celsius. Proper storage helps maintain the effectiveness of the drug.

Appearance

White to almost white rectangular film-coated tablets

Package unit

1 tablet / PTP