Cizal Solution (Levocetirizine Hydrochloride)

Adult dose

Adults and children aged 6 and older: 5mg of levocetirizine hydrochloride (10mL as a liquid), administered orally once a day, regardless of meals. Adult patients with renal impairment should adjust the dosage based on kidney function (estimated glomerular filtration rate (eGFR)). - Normal kidney function (≥ 90 mL/min): 5mg once a day - Mild renal impairment (60 -< 90 mL/min): 5mg once a day - Moderate renal impairment (30 -< 60 mL/min): 5mg once every 2 days Severe renal impairment (15 -< 30 mL/min): does not require dialysis. 5mg once every 3 days End-stage renal disease (< 15 mL/min): requires dialysis contraindicated. Pediatric patients with renal impairment should have their dosage adjusted based on kidney function and weight.

Child dose

Children aged 2 years and older and less than 6 years: 1.25mg (2.5mL as a liquid), administered orally twice a day. Children aged 1 year and older and less than 2 years: 1.25mg (2.5mL as a liquid), administered orally once a day.

This medication should not be used by patients who have had allergic reactions to specific ingredients, patients with end-stage renal disease, and infants under 1 year of age. In children under 6 years old, it should only be administered in liquid form and not in tablet form, as the liquid contains maltitol, which should not be given to patients who do not tolerate fructose. Patients with impaired kidney or liver function and the elderly should use this drug cautiously, as blood concentration may increase. Varied side effects such as drowsiness, headache, dizziness, vomiting, and diarrhea may occur during use; if symptoms are severe or persistent, consult a doctor. This medication may cause drowsiness or fatigue, so caution is necessary when driving or operating machinery. Taking this medication with alcohol or other central nervous system depressants may increase drowsiness; therefore, it is advisable not to take them together. Patients with urinary excretion issues, liver disease, or a risk of seizures should take special care when using this drug. The liquid formulation contains preservatives and sweeteners that may cause allergic reactions or health issues, so caution should be exercised in those with sensitivities. Women who are pregnant or nursing should consult a doctor before taking this medication, as there is insufficient safety data. It is safer not to use this medication in children, especially infants under 1 year of age, due to limited experience in use. The elderly may have reduced kidney function, so they should start with a lower dose and adjust while monitoring their condition. It is advisable to temporarily discontinue this medication prior to allergy testing, as it may affect test results. In case of overdose, symptoms such as drowsiness or anxiety may occur, and there is no specific antidote, so symptomatic treatment should be provided. This medication is not removed by hemodialysis, so hemodialysis may not be effective in cases of overdose.

Serious side effects

• Urticaria
• anaphylaxis shock
• angioedema
• hypertension
• respiratory distress

Mild side effects

• Drowsiness
• lethargy
• headache
• numbness
• anxiety
• drowsiness
• fatigue
• dizziness
• heavy feeling
• excitement

This medication is sensitive to light; therefore, it should be stored in a container that blocks light. Additionally, it should be kept at room temperature between 1 to 30 degrees Celsius. Proper storage can help maintain the drug's effectiveness for a longer period.

Appearance

Colorless and transparent solution in a brown glass bottle

Package unit

200 mL