BC Vancomycin Hydrochloride Injection 500 mg

Adult dosage

As vancomycin, administer 500 mg (potency) by intravenous drip every 6 hours or 1 g (potency) every 12 hours. For oral administration, administer 500 to 2000 mg divided into 3 to 4 doses for 7 to 10 days, with a total daily dosage not exceeding 2 g.

Children's dosage

Administer 10 mg/kg (potency) by intravenous injection every 6 hours. For infants, administer 10 to 15 mg/kg (potency) by intravenous injection every 12 hours. For infants and newborns, an initial dose of 15 mg/kg is recommended.

This drug should not be used in patients who have previously experienced severe allergic reactions or shock due to this medication. Additionally, patients with allergies to this drug or peptide and aminoglycoside antibiotics should not be treated. Patients with hearing loss or those who have experienced hearing loss related to the use of similar medications should use this drug with caution. In patients with poor kidney function, the drug may accumulate in the body, so blood concentration should be regularly monitored and dosages adjusted. This drug may also worsen liver function in patients with impaired liver function, so caution is required. Elderly patients, premature infants, and newborns should be administered this drug with greater caution due to immature or compromised kidney function. Patients with damage to the vestibular or auditory organs should also be cautious when using this medication. This drug can rarely cause serious allergic reactions such as shock or anaphylaxis, so symptoms should be closely monitored during administration. Gastrointestinal symptoms may include loose stool, diarrhea, nausea, vomiting, and abdominal pain. Hematological side effects can include a decrease in red blood cells, white blood cells, and platelets, and in some cases, severe blood abnormalities such as agranulocytosis have been reported. Symptoms like dizziness, tinnitus, and hearing loss may occur in the central nervous system, so regular hearing tests are recommended. Liver function tests may show elevated bilirubin and liver enzyme levels, so liver function should be monitored periodically. Side effects related to decreased kidney function may also occur, requiring regular tests for blood urea nitrogen (BUN) and creatinine levels, with dosage adjustments as needed. Serious skin reactions such as severe dermatitis, vesicular dermatitis, and Stevens-Johnson syndrome may occur, so careful observation of skin conditions is necessary. Allergic reactions can cause rashes, hives, and difficulty breathing, and if the infusion rate is too fast, erythema or pain in the face, neck, and trunk, as well as muscle cramps may occur. To prevent the occurrence of resistant bacteria, it is important to conduct sensitivity tests and only administer the drug for the minimal necessary duration. Patients with decreased kidney function should be careful about maintaining blood concentration, and the risk of nephrotoxicity is increased when combined with aminoglycoside antibiotics, so kidney function should be closely monitored. Serious intestinal infections such as antibiotic-associated colitis can occur, so if diarrhea, abdominal pain, or fever persist, administration should be immediately halted. Long-term use can lead to the proliferation of resistant bacteria, and if the balance is disrupted, drug administration should be ceased, and appropriate treatment should be obtained. Regular hearing tests are recommended to minimize the risk of auditory toxicity. Routine blood tests, liver function, and kidney function assessments should be performed during administration to detect abnormal reactions early. Pregnant women or those who could become pregnant should only use this drug cautiously when treatment is absolutely necessary, as the effects on the fetus are not fully understood. Breastfeeding mothers should avoid administration of this drug or, if absolutely necessary, discontinue breastfeeding as the drug can be transferred into breast milk. Children, especially premature infants and newborns, should have dosages and administration intervals adjusted carefully due to immature kidney function, which may result in prolonged retention of the drug in the body. Elderly patients commonly experience decreased kidney function, so assessments of kidney function should be conducted before and during administration, and dosages adjusted as necessary. In cases of overdose, severe side effects such as acute renal failure or hearing loss can occur, requiring immediate proper treatment, as this drug is not removed by dialysis and requires specific treatment methods. This drug can irritate tissues, so it must be administered intravenously, avoiding intramuscular injections or careless injections. Rapid infusion at high concentrations may lead to thrombophlebitis, hypotension, cardiac arrest, and must be infused slowly over a minimum of 60 minutes. This drug can cause chemical instability if mixed with other medications, particularly alkaline solutions or beta-lactam antibiotics should be avoided.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, rash, erythema, facial flushing, hypotension, wheezing, shortness of breath, exfoliative dermatitis, vesicular dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, drug hypersensitivity syndrome (DRESS), acute generalized exanthematous pustulosis (AGEP), severe allergic reactions, severe skin reactions, jaundice, severe skin adverse reactions, acute generalized exanthematous.

Mild side effects

• Loose stool
• diarrhea
• nausea
• vomiting
• abdominal pain
• decrease in red blood cells
• decrease in white blood cells
• decrease in platelets
• increase in eosinophils
• dizziness

This drug should be stored in a sealed container to prevent exposure to air and kept at room temperature between 1 and 30 degrees Celsius. This will help maintain the drug's effectiveness.

Appearance

A white to light yellow-brown freeze-dried powder in a colorless and transparent vial.

Package unit

10 vials