Famir Tablets (Famciclovir)

Adult dose

1. Treatment of herpes zoster Adults: Administer famciclovir 250 mg per dose orally 3 times daily for 7 days. It is advisable to start treatment as soon as symptoms appear after infection. 2. Treatment of an initial episode of genital herpes Adults: Administer 250 mg of this drug per dose orally 3 times daily for 5 days. It is advisable to start treatment as soon as symptoms appear after infection. 3. Treatment of acute recurrent genital herpes Adults: Administer 125 mg of this drug per dose orally 2 times daily for 5 days. It is advisable to start treatment during the prodromal period or as soon as symptoms appear after infection. 4. Suppression of recurrent genital herpes Adults: Administer 250 mg of this drug per dose orally 2 times daily. Discontinue treatment periodically every 6～12 months to observe whether the natural course of the disease has changed. 5. Patients with renal impairment: Because creatinine clearance of this drug is decreased in patients with renal impairment, dose adjustment should be made with care. The dosage and administration for these patients are as follows. 1) Treatment of herpes zoster and an initial episode of genital herpes: Creatinine clearance (mL/min/1.73㎡) 30～59: 250 mg per dose 2 times daily 10～29: 250 mg per dose once daily 2) Treatment of acute recurrent genital herpes: Creatinine clearance (mL/min/1.73㎡) 30～59: 125 mg per dose 2 times daily 10～29: 125 mg per dose once daily 3) Suppression of recurrent genital herpes: Creatinine clearance (mL/min/1.73㎡) 30～59: 250 mg per dose 2 times daily 10～29: 125 mg per dose 2 times daily 4) If only serum creatinine is known, creatinine clearance can be calculated using the following formulas. Men: {body weight (kg) × (140-age)}/ {72 × serum creatinine (mg/dL)} Women: 0.85 × the value calculated for men 5) Patients with renal impairment undergoing hemodialysis It is advisable to administer the drug every 48 hours, taking the dialysis interval into account. Four hours of hemodialysis reduces the plasma concentration of this drug by approximately 75%; therefore, administer this drug immediately after dialysis. The recommended dose is 250mg for patients with herpes zoster and 125mg for patients with genital herpes. 6. Patients with hepatic impairment: No dose adjustment is required for patients with chronic compensated liver disease. There is insufficient treatment experience in patients with overt chronic decompensated liver disease; therefore, no clear recommended dose has been established.

This medication should not be used by individuals who are allergic to this medication or its components. Additionally, this medication contains lactose, so it should not be administered to patients with lactose intolerance or certain genetic metabolic disorders. Patients with renal impairment need to be cautious when using this medication, and dose adjustment may be necessary. During the use of this medication, side effects such as headache, dizziness, nausea, vomiting, and skin rash may occur; if symptoms are severe, consult a healthcare provider. This medication does not completely cure genital herpes, so it is important to avoid sexual contact and maintain safe sexual practices if symptoms occur during treatment. If dizziness, drowsiness, or confusion occurs during treatment, avoid driving or operating machinery. Generally, elderly patients do not require dose adjustments; however, if renal function is impaired, dosage should be adjusted. In case of overdose, promptly visit a medical institution for appropriate treatment; hemodialysis may remove some components of this medication. This medication should be stored in a dry place below 30 degrees Celsius, out of reach of children. Avoid transferring the medication to another container, as this may cause a decrease in quality or result in accidents.

• headache
• nausea
• thrombocytopenia
• leukopenia
• neutropenia
• dizziness
• confusion
• drowsiness
• hallucination
• palpitations

This medication is sensitive to air and moisture, so it should be stored in a sealed container. It is also advisable to keep it in a cool, dry place below 30 degrees Celsius.

Appearance

White round film-coated tablets

Package unit

21 tablets (3 PTP packs of 7 tablets each)