Paviar Tablet (Famciclovir)

Adult dose

1. Treatment of herpes zoster Adults: Administer famciclovir orally at a dose of 750 mg once daily for 7 days. Take it at the same time each day. It is preferable to start treatment as soon as symptoms appear after infection. 2. Patients with renal impairment: Because the creatinine clearance of this drug is reduced in patients with renal impairment, dose adjustments should be made with caution. The dosage and administration for these patients are as follows. 1) Treatment of herpes zoster Creatinine clearance (mL/min/1.73㎡) 30–59 250 mg per dose, twice daily 10–29 250 mg per dose, once daily 2) If only serum creatinine is known, creatinine clearance can be calculated using the following formula. Men: {body weight (kg) × (140-age)}/ {72 × serum creatinine (mg/dL)} Women: 0.85 × the value calculated for men 3) Patients with renal impairment undergoing hemodialysis: For patients on hemodialysis, administration every 48 hours is preferable, taking the dialysis interval into account. Because 4 hours of hemodialysis reduces the plasma concentration of this drug by approximately 75%, administer the full dose of this drug immediately after dialysis. 3. Patients with hepatic impairment: No dose adjustment is required for patients with chronic compensated liver disease. There is insufficient treatment experience in patients with overt chronic decompensated liver disease; therefore, a clear recommended dose has not been established.

This medication should not be administered to certain patients. In particular, patients who have had allergic reactions to this medication or its main ingredient, penciclovir, or those with specific genetic issues such as lactose intolerance should not take it. Patients with renal impairment should use this medication with caution, and dose adjustment may be necessary. When taking this medication, side effects such as headache, nausea, vomiting, dizziness, and skin rash may occur, and severe side effects such as decreased blood cell count or liver dysfunction have also been reported in some patients. This medication does not cure genital herpes; therefore, even during treatment, sexual contact should be avoided and safe sexual practices should be maintained if symptoms occur. Caution is required when driving or operating machinery due to the potential for dizziness or drowsiness. Generally, elderly patients do not need dose adjustments, but those with impaired kidney function may need dosage adjustments. In case of overdose, appropriate treatment should be sought, and if necessary, hemodialysis can be used to lower drug concentration. This medication should be stored in a dry place at temperatures below 30 degrees Celsius and kept out of reach of children, and it is advisable not to transfer it to other containers.

• Headache
• nausea
• thrombocytopenia
• leukopenia
• neutropenia
• dizziness
• confusion
• drowsiness
• hallucination
• palpitations

This medication must be stored in a tightly sealed container to prevent exposure to air or moisture. Additionally, it is recommended to store it in a cool and dry place below 25 degrees Celsius. This will help maintain the medication's effectiveness over time.

Appearance

White oblong film-coated tablet

Package unit

7 tablets/PTP