Zovirax 250 mg Tablets (Famciclovir)

Adult dose

1. Treatment of herpes zoster Adults: Administer famciclovir orally at a dose of 250 mg 3 times daily for 7 days. It is preferable to start treatment as soon as symptoms appear after infection. 2. Treatment of first-episode genital herpes Adults: Administer this drug orally at a dose of 250 mg 3 times daily for 5 days. It is preferable to start treatment as soon as symptoms appear after infection. 3. Treatment of acute recurrent genital herpes Adults: Administer this drug orally at a dose of 125 mg 2 times daily for 5 days. It is preferable to start treatment during the prodromal period or as soon as symptoms appear after infection. 4. Suppression of recurrent genital herpes Adults: Administer this drug orally at a dose of 250 mg 2 times daily. Temporarily discontinue treatment periodically every 6～12 months to assess whether the natural course of the disease has changed. 5. Patients with renal impairment: Because creatinine clearance of this drug is reduced in patients with renal impairment, dose adjustment should be undertaken with caution. The dosage and administration for these patients are as follows. 1) Treatment of herpes zoster and first-episode genital herpes: Creatinine clearance (mL/min/1.73㎡) Dose 30～59 250 mg per dose, 2 times daily 10～29 250 mg per dose, once daily 2) Treatment of acute recurrent genital herpes: Creatinine clearance (mL/min/1.73㎡) Dose 30～59 125 mg per dose, 2 times daily 10～29 125 mg per dose, once daily 3) Suppression of recurrent genital herpes: Creatinine clearance (mL/min/1.73㎡) Dose 30～59 250 mg per dose, 2 times daily 10～29 125 mg per dose, 2 times daily 4) If only serum creatinine is known, creatinine clearance can be calculated using the following formula. Men: {weight (kg) × (140-age)}/ {72 × serum creatinine (mg/dL)} Women: 0.85 × the value calculated for men 5) Patients with renal impairment undergoing hemodialysis It is preferable to administer the drug every 48 hours, taking the interval between dialysis sessions into account. Because 4 hours of hemodialysis reduces the plasma concentration of this drug by approximately 75%, administer this drug immediately after dialysis. The recommended dose is 250mg for patients with herpes zoster and 125mg for patients with genital herpes. 6. Patients with hepatic impairment: No dose adjustment is necessary in patients with chronic compensated liver disease. There is insufficient treatment experience in patients with overt chronic decompensated liver disease; therefore, a clear recommended dose has not been established.

This medication should not be used by patients allergic to this medication or any of its components. This medication contains lactose, so patients with genetic issues like galactose intolerance, lactase deficiency, or glucose-galactose malabsorption should not take it. Patients with impaired kidney function should be cautious when using this medication, and dose adjustment may be necessary. While taking this medication, symptoms such as headache, dizziness, nausea, vomiting, abdominal pain, and diarrhea may occur, and serious side effects such as thrombocytopenia or acute renal failure have been reported, though rarely. Skin rashes or itching, and rarely severe skin reactions can occur, so if any unusual symptoms arise, consultation with a healthcare professional should be sought immediately. This medication does not completely cure genital herpes, so it is important to avoid sexual contact when symptoms are present and to maintain safe sex practices. If dizziness, drowsiness, or confusion occurs during treatment, driving or operating machinery should be avoided. Patients with mild liver function impairment do not require special dose adjustments; however, patients with severe liver dysfunction should be cautious as the efficacy may decrease. This medication has a low potential for drug interactions, but co-administration with certain drugs like probenecid may increase drug levels, which should be monitored for toxicity. Pregnant women or those who may become pregnant should carefully consider the benefits and risks before using this medication, and breastfeeding mothers should also exercise caution. Children under 18 years old are not recommended to use this medication as its safety and efficacy have not been established. Elderly patients generally do not require dose adjustments; however, those with decreased renal function should have their doses adjusted. In the case of overdose, appropriate treatment should be administered, and blood dialysis can reduce the concentration of the active ingredients in this medication. This medication should be stored in a cool, dry place below 30 degrees, and kept in a secure location out of reach of children. Care should be taken to avoid transferring it to other containers as it may lead to accidents.

• headache
• nausea
• thrombocytopenia
• leukopenia
• neutropenia
• dizziness
• confusion
• drowsiness
• hallucination
• palpitations

This medication should be stored in a tightly sealed container to avoid exposure to air or moisture. Additionally, it should be kept in a cool, dry place below 30 degrees.

Appearance

White, round, film-coated tablet

Package unit

21 tablets/bottle