Famciclovir 250 mg Tablet

Adult dose

1. Treatment of herpes zoster Adults: Administer famciclovir orally at a dose of 250 mg 3 times daily for 7 days. It is preferable to start treatment as soon as symptoms appear after infection. 2. Treatment of first-episode genital herpes Adults: Administer this drug orally at a dose of 250 mg 3 times daily for 5 days. It is preferable to start treatment as soon as symptoms appear after infection. 3. Treatment of acute recurrent genital herpes Adults: Administer this drug orally at a dose of 125 mg 2 times daily for 5 days. It is preferable to start treatment during the prodromal period or as soon as symptoms appear after infection. 4. Suppression of recurrent genital herpes Adults: Administer this drug orally at a dose of 250 mg 2 times daily. Temporarily discontinue treatment periodically every 6～12 months to assess whether the natural course of the disease has changed. 5. Patients with renal impairment: Because creatinine clearance of this drug is reduced in patients with renal impairment, dose adjustment should be undertaken with caution. The dosage and administration for these patients are as follows. 1) Treatment of herpes zoster and first-episode genital herpes: Creatinine clearance (mL/min/1.73㎡) 30～59: 250 mg per dose, 2 times daily Creatinine clearance (mL/min/1.73㎡) 10～29: 250 mg per dose, once daily 2) Treatment of acute recurrent genital herpes: Creatinine clearance (mL/min/1.73㎡) 30～59: 125 mg per dose, 2 times daily Creatinine clearance (mL/min/1.73㎡) 10～29: 125 mg per dose, once daily 3) Suppression of recurrent genital herpes: Creatinine clearance (mL/min/1.73㎡) 30～59: 250 mg per dose, 2 times daily Creatinine clearance (mL/min/1.73㎡) 10～29: 125 mg per dose, 2 times daily 4) If only serum creatinine is known, creatinine clearance can be calculated using the following formula. Men: {weight (kg) × (140-age)}/ {72 × serum creatinine (mg/dL)} Women: 0.85 × the value calculated for men 5) Patients with renal impairment undergoing hemodialysis It is preferable to administer the drug every 48 hours, taking the interval between dialysis sessions into account. Because 4 hours of hemodialysis reduces the plasma concentration of this drug by approximately 75%, administer this drug immediately after dialysis. The recommended dose is 250mg for patients with herpes zoster and 125mg for patients with genital herpes. 6. Patients with hepatic impairment: No dose adjustment is necessary in patients with chronic compensated liver disease. There is insufficient treatment experience in patients with overt chronic decompensated liver disease; therefore, a clear recommended dose has not been established.

This medication should not be used by patients allergic to specific components. It contains lactose, so patients with difficulties digesting lactose should not take it. Caution is needed when using this medication in patients with impaired kidney function. This medication does not completely cure genital herpes, so it is advisable to avoid sexual contact when symptoms are present. Dizziness or drowsiness may occur during usage, so caution should be exercised when driving or operating machinery. Patients with severe liver dysfunction may experience reduced effectiveness of this medication. Side effects such as headache, nausea, dizziness, skin rash may occur, and if any unusual symptoms appear, consulting a doctor is necessary. There may be interactions when taken with other medications, so it is essential to inform your physician or pharmacist. Women who are pregnant or breastfeeding should consult a doctor before taking this medication. Its safety has not been established in children under 18 years of age, so it is advisable not to use it in this population. Elderly patients may require dose adjustments based on kidney function. In case of overdose, treatment such as dialysis may be necessary. This medication should be stored in a tightly closed container in a dry place at temperatures below 30 degrees Celsius and kept out of reach of children.

• headache
• nausea
• thrombocytopenia
• leukopenia
• neutropenia
• dizziness
• confusion
• drowsiness
• hallucinations
• palpitations

This medication should be stored in a tightly closed container to prevent air or moisture exposure, preferably in a cool place below 30 degrees Celsius. This way, the medication's effectiveness can be maintained and deterioration can be prevented.

Appearance

White, round, film-coated tablet

Package unit

21 tablets/bottle