Famciclovir Tablets (Famciclovir)

Adult dose

1. Treatment of herpes zoster Adults: Administer famciclovir orally at a dose of 250 mg three times daily for 7 days. It is preferable to start treatment as soon as symptoms appear after infection. 2. Treatment of an initial episode of genital herpes Adults: Administer this drug orally at a dose of 250 mg three times daily for 5 days. It is preferable to start treatment as soon as symptoms appear after infection. 3. Treatment of acute recurrent genital herpes Adults: Administer this drug orally at a dose of 125 mg twice daily for 5 days. It is preferable to start treatment during the prodromal period or as soon as symptoms appear after infection. 4. Suppression of recurrent genital herpes Adults: Administer this drug orally at a dose of 250 mg twice daily. Discontinue treatment periodically every 6～12 months to assess whether the natural course of the disease has changed. 5. Patients with renal impairment: Since the creatinine clearance of this drug is reduced in patients with renal impairment, dosage adjustment should be made with care. The dosage and administration for these patients are as follows. 1) Treatment of herpes zoster and initial genital herpes infection: Creatinine clearance (mL/min/1.73㎡) Dose 30～59 250 mg per dose twice daily 10～29 250 mg per dose once daily 2) Treatment of acute recurrent genital herpes: Creatinine clearance (mL/min/1.73㎡) Dose 30～59 125 mg per dose twice daily 10～29 125 mg per dose once daily 3) Suppression of recurrent genital herpes: Creatinine clearance (mL/min/1.73㎡) Dose 30～59 250 mg per dose twice daily 10～29 125 mg per dose twice daily 4) If only serum creatinine is known, creatinine clearance can be calculated using the following formula. Men: {body weight (kg) × (140-age)}/ {72 × serum creatinine (mg/dL)} Women: 0.85 × the value calculated for men 5) Patients with renal impairment undergoing hemodialysis For patients undergoing hemodialysis, administration every 48 hours is preferable, taking the interval between dialysis sessions into consideration. Since 4 hours of hemodialysis reduces the plasma concentration of this drug by approximately 75%, administer this drug immediately after dialysis. The recommended dose is 250mg for patients with herpes zoster and 125mg for patients with genital herpes. 6. Patients with hepatic impairment: No dosage adjustment is required in patients with chronic compensated liver disease. There is insufficient treatment experience in patients with overt chronic decompensated liver disease; therefore, a clear recommended dose has not been established.

This medication should not be administered to certain patients. It should not be used in patients who have had an allergic reaction to this medication, its components, or the active substance, penciclovir. Additionally, this medication contains lactose, so it should not be given to patients with genetic diseases that prevent the digestion of lactose. Patients with impaired renal function should use this medication with caution, and dosage adjustments may be necessary. Side effects such as headache, dizziness, nausea, vomiting, and skin rash may occur while taking this medication; if symptoms are severe or persistent, consult a doctor. This medication does not cure genital herpes, so it is important to avoid sexual contact and maintain safe sexual practices during treatment. If dizziness, drowsiness, or confusion occurs, avoid driving or operating machinery. Patients with mildly impaired liver function do not require special dosage adjustment, but in severe liver disease, efficacy may diminish. This medication may interact with other drugs, so if you are taking other medications, be sure to inform your doctor or pharmacist. Women who are pregnant or may become pregnant, or those who are breastfeeding, should use this medication with caution and only when the benefits of treatment outweigh the risks. Children under 18 are advised not to use this medication, as its safety and efficacy have not been established. Generally, the elderly do not require dosage adjustments, but dosage may need to be adjusted if renal function is poor. In case of overdose, appropriate treatment is necessary, and hemodialysis can reduce the concentration of the active substance in this medication. Store this medication in a dry place below 30 degrees Celsius and keep it out of the reach of children, avoiding transferring it to another container.

• headache
• nausea
• thrombocytopenia
• leukopenia
• neutropenia
• dizziness
• confusion
• drowsiness
• hallucination
• palpitations

This medication is sensitive to air and moisture, so it should be stored in a tightly sealed container. Also, store it in a dry place below 30 degrees Celsius to maintain its efficacy.

Appearance

White circular film-coated tablets

Package unit

21 tablets (7 tablets/PTP x 3)