Famciclovir 250 mg Tablet

Adult dose

1. Treatment of herpes zoster Adults: Administer famciclovir orally at a dose of 250 mg 3 times daily for 7 days. It is preferable to start treatment as soon as symptoms appear after infection. 2. Treatment of initial genital herpes Adults: Administer this drug orally at a dose of 250 mg 3 times daily for 5 days. It is preferable to start treatment as soon as symptoms appear after infection. 3. Treatment of acute recurrent genital herpes Adults: Administer this drug orally at a dose of 125 mg twice daily for 5 days. It is preferable to start treatment during the prodromal period or as soon as symptoms appear after infection. 4. Suppression of recurrent genital herpes Adults: Administer this drug orally at a dose of 250 mg twice daily. Discontinue treatment periodically every 6～12 months to assess whether the natural course of the disease has changed. 5. Patients with renal impairment As creatinine clearance of this drug is reduced in patients with renal impairment, adjust the dose with caution. The dosage and administration for these patients are as follows. 1) Treatment of herpes zoster and initial genital herpes: Creatinine clearance (mL/min/1.73㎡) 30～59: 250 mg per dose, twice daily 10～29: 250 mg per dose, once daily 2) Treatment of acute recurrent genital herpes: Creatinine clearance (mL/min/1.73㎡) 30～59: 125 mg per dose, twice daily 10～29: 125 mg per dose, once daily 3) Suppression of recurrent genital herpes: Creatinine clearance (mL/min/1.73㎡) 30～59: 250 mg per dose, twice daily 10～29: 125 mg per dose, twice daily 4) If only serum creatinine is known, creatinine clearance may be calculated using the following formula. Men: {weight(kg) × (140-age)}/ {72 × serum creatinine(mg/dL)} Women: 0.85 × the value calculated for men 5) Patients with renal impairment undergoing hemodialysis For patients on hemodialysis, administration every 48 hours is recommended, taking the dialysis interval into account. As 4 hours of hemodialysis reduces plasma concentrations of this drug by approximately 75%, administer this drug immediately after dialysis. The recommended dose is 250mg for patients with herpes zoster and 125mg for patients with genital herpes. 6. Patients with hepatic impairment No dose adjustment is necessary for patients with chronic compensated liver disease. There is insufficient treatment experience in patients with overt chronic decompensated liver disease; therefore, no clear recommended dose has been established.

This medication should not be used in certain patients. Specifically, individuals who are allergic to this drug or its components, or who have genetic issues such as lactose intolerance, should not take it. Caution is required when using this drug in patients with impaired kidney function. Side effects such as headaches, nausea, and dizziness may occur, but they are mostly mild. Rarely, there may be a decrease in blood cell count, skin rashes, itching, palpitations, and liver function abnormalities. Additionally, patients with poor kidney function may be at risk for acute renal failure, so caution is essential. This medication does not completely cure genital herpes, and sexual contact should be avoided when symptoms are present. If dizziness or drowsiness occurs during treatment, driving or operating machinery should be avoided. In patients with slightly impaired liver function, dose adjustments are not necessary; however, in patients with severe liver impairment, the efficacy may be reduced. This drug does not have significant interactions with other medications, but caution is required when taken with certain drugs. Pregnant or nursing women should consult a physician before using this drug, and women of childbearing potential should use it with caution. Children under 18 years old should not use this medication as safety and efficacy have not been established. Generally, elderly patients do not need dose adjustments, but dosage should be adjusted in those with poor kidney function. In cases of overdose, proper treatment is required, and blood dialysis can reduce drug concentration. This drug should be stored in a dry place below 30 degrees Celsius and kept out of reach of children. Additionally, it should be avoided to transfer it to another container.

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This medication may be sensitive to air or moisture, so it should be stored in a tightly sealed container. Additionally, it should be stored in a cool and dry place below 30 degrees Celsius to maintain its effectiveness.

Appearance

White round film-coated tablet

Package unit

21 tablets/bottle