Famciclovir 250 mg Tablet

Adult dose

1. Treatment of herpes zoster Adults: Administer 250 mg of famciclovir orally 3 times daily for 7 days. It is preferable to start treatment as soon as symptoms appear after infection. 2. Treatment of initial genital herpes infection Adults: Administer 250 mg of this medicine orally 3 times daily for 5 days. It is preferable to start treatment as soon as symptoms appear after infection. 3. Treatment of acute recurrent genital herpes infection Adults: Administer 125 mg of this medicine orally 2 times daily for 5 days. It is preferable to start treatment during the prodromal period or as soon as symptoms appear after infection. 4. Suppression of recurrent genital herpes Adults: Administer 250 mg of this medicine orally 2 times daily. Discontinue treatment periodically every 6～12 months to assess whether the natural course of the disease has changed. 5. Patients with renal impairment: Since the creatinine clearance of this medicine is reduced in patients with renal impairment, dose adjustment should be undertaken with care. The dosage for these patients is as follows. 1) Treatment of herpes zoster and initial genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59: 250 mg per dose, 2 times daily 10～29: 250 mg per dose, once daily 2) Treatment of acute recurrent genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59: 125 mg per dose, 2 times daily 10～29: 125 mg per dose, once daily 3) Suppression of recurrent genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59: 250 mg per dose, 2 times daily 10～29: 125 mg per dose, 2 times daily 4) If only serum creatinine is known, creatinine clearance can be calculated using the following equations. Men: {body weight (kg) × (140-age)}/ {72 × serum creatinine (mg/dL)} Women: 0.85 × the value calculated for men 5) Patients with renal impairment undergoing hemodialysis For patients on hemodialysis, administration every 48 hours is preferable, taking the dialysis interval into account. A 4-hour hemodialysis session reduces the plasma concentration of this medicine by approximately 75%; therefore, administer this medicine immediately after dialysis. The recommended dose is 250mg for patients with herpes zoster and 125mg for patients with genital herpes. 6. Patients with hepatic impairment: No dose adjustment is necessary for patients with compensated chronic liver disease. Since there is insufficient treatment experience in patients with overt chronic decompensated liver disease, no definitive recommended dose has been established.

This medication should not be used by patients who are allergic to this drug or its components, or who have genetic issues such as lactose intolerance. Patients with impaired kidney function should use this drug with caution, and dosage adjustments may be necessary. Mild side effects such as headache or nausea may occur, and rarely thrombocytopenia, leukopenia, dizziness, drowsiness, hallucinations, palpitations, skin rash, and itching have been reported. This drug does not completely cure genital herpes, so it is important to avoid sexual contact during symptoms and maintain safe sexual practices. If experiencing dizziness or drowsiness while taking this medication, driving or operating machinery should be avoided. Patients with slightly impaired liver function do not require special dosage adjustments, but severely impaired liver function may reduce efficacy. This medication has minimal drug interactions, but caution should be exercised when taken with certain drugs like probenecid, as it may increase blood concentration and risk of side effects. Women who are pregnant or breastfeeding should have careful consideration regarding the use of this drug, as should women of childbearing potential. Children under 18 years should generally avoid use, as safety and efficacy have not been established. Older adults typically do not need dosage adjustments, but dosage adjustments may be necessary if kidney function is decreased. In the case of overdose, treatment should be based on symptoms, and hemodialysis can reduce the concentration of the active ingredient of this drug. This medication should be stored in a dry place below 30 degrees Celsius, out of reach of children, and transferring it to another container should be avoided.

• Headache
• nausea
• thrombocytopenia
• leukopenia
• neutropenia
• dizziness
• confusion
• drowsiness
• hallucination
• palpitations

This medication is sensitive to air and moisture, so it should be stored in a sealed container. Additionally, it is recommended to store it in a cool and dry place below 30 degrees Celsius.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle