Phamvix 750 mg Tablet (Famciclovir)

Adult dose

1. Treatment of herpes zoster infection Adults: Administer 750 mg of famciclovir orally once daily for 7 days. Take it at the same time every day. It is preferable to start treatment as soon as symptoms appear after infection. 2. Patients with renal impairment: Since the creatinine clearance of this drug is reduced in patients with renal impairment, dose adjustment should be made with care. The dosage and administration for these patients are as follows. 1) Treatment of herpes zoster infection Creatinine clearance (mL/min/1.73㎡) Dose 30～59 250 mg per dose, twice daily 10～29 250 mg per dose, once daily 2) If only the serum creatinine level is known, creatinine clearance can be calculated using the following formulas. Men: {body weight (kg) × (140-age)}/ {72 × serum creatinine (mg/dL)} Women: 0.85 × the value calculated for men 3) Patients with renal impairment undergoing hemodialysis: In patients undergoing hemodialysis, administration every 48 hours is preferable, taking the dialysis interval into account. Since 4 hours of hemodialysis reduces the plasma concentration of this drug by approximately 75%, administer the full dose of this drug immediately after dialysis. 3. Patients with hepatic impairment: No dose adjustment is necessary in patients with chronic compensated liver disease. There is insufficient treatment experience in patients with evident chronic decompensated liver disease; therefore, no specific recommended dose has been established.

This drug should not be used in certain patients. It should not be administered to patients who have had an allergic reaction to this drug, its components, or the active substance, famciclovir. Additionally, since it contains lactose, patients with genetic issues such as lactose intolerance, lactose deficiency, or glucose-galactose malabsorption should not take this drug. Caution is needed when using this drug in patients with poor kidney function. The dosage of the medication may need to be adjusted based on kidney function. Taking this drug may cause symptoms such as headaches or nausea, most of which are mild or moderate. Decreased blood cell counts, dizziness, confusion, drowsiness, and hallucinations have also been reported as neurological symptoms. In the gastrointestinal system, nausea, vomiting, abdominal pain, and diarrhea can commonly occur. Liver function abnormalities or skin rashes, itching, and, rarely, severe skin reactions may also occur, so if any abnormal symptoms arise, immediate consultation with healthcare professionals is necessary. This drug does not completely treat genital herpes, and it is important to avoid sexual contact if symptoms persist during treatment. Maintaining safe sexual practices during treatment is recommended. Patients should be educated to start treatment immediately upon the appearance of recurrent symptoms. This drug generally does not affect driving or operating machinery, but if dizziness, drowsiness, or confusion occurs during treatment, driving or operating machinery should be avoided. Patients with slightly reduced liver function do not require special dosage adjustments, but those with severe liver impairment should use caution as the efficacy may be reduced. This drug is known not to interact significantly with other medications, but caution is advised when used in combination with certain drugs due to potential changes in drug concentration or side effects, so patients should inform their healthcare provider about the medications they are taking. Women who are pregnant or may become pregnant should have careful consideration before taking this drug, and breastfeeding women should only take it if necessary. Children under 18 years of age should not use this drug as its safety and efficacy have not been established. Elderly patients generally do not require dosage adjustment, but dosage should be adjusted in patients with poor kidney function. In case of overdose, immediate medical attention should be sought, and blood dialysis can be used to reduce drug concentration. This drug should be stored in a cool, dry place below 30 degrees Celsius and kept out of reach of children. Transferring to other containers is not advisable as it may affect quality.

• Headache
• nausea
• thrombocytopenia
• leukopenia
• neutropenia
• dizziness
• confusion
• drowsiness
• hallucinations
• palpitations

This drug is sensitive to air and moisture, so it must be stored in a tightly sealed container. Additionally, it is important to keep it in a cool, dry place at a temperature below 30 degrees Celsius.

Appearance

White oval film-coated tablet

Package unit

7 tablets (7 tablets/PTP x 1)