Metophag XR Sustained Release Tablet 500mg (Metformin Hydrochloride)

Adult dosage

The typical initial dose is 500mg of Metformin Hydrochloride Extended Release Tablet once daily with the evening meal. After one week, measure blood sugar levels to adjust the dosage, which can be increased by 500mg weekly up to a maximum of 2000mg taken with the evening meal. If blood sugar control is not achieved even after maximum dosage of 2000mg once daily, consider taking 1000mg twice daily with meals.

This medication can rarely cause a serious condition called lactic acidosis, which can be life-threatening, so caution is required. In addition, hypoglycemic symptoms may occur when used with insulin or sulfonylurea drugs, so caution should be exercised. Patients with moderate to severe renal impairment, dehydration, severe infections, acute heart conditions, etc., should not use this medication. Patients with acute heart failure or those scheduled for tests using iodinated contrast agents should also avoid using this medication. Patients with allergies to this medication's ingredients or those with type 1 diabetes or diabetic ketoacidosis should not be administered this medication. In cases of severe infections, trauma, or surgery, the use of this medication should be temporarily discontinued and resumed only once the condition has recovered. Patients with impaired liver function or those consuming excessive alcohol should also refrain from using this medication. Pregnant women or women who may become pregnant should not use this medication. Patients who have irregular meal patterns, engage in vigorous exercise, or are taking other medications should use this medication with caution due to the risk of lactic acidosis and hypoglycemia. This medication may cause side effects such as gastrointestinal disturbances, altered taste, skin rashes, etc., and during the initial phase, symptoms like nausea, vomiting, and diarrhea may commonly occur. Renal function should be regularly monitored to ensure that the medication does not accumulate excessively in the body, and if renal function deteriorates rapidly, the use of this medication should be discontinued. Alcohol consumption may increase the risk of side effects of this medication, so it is advisable to avoid alcohol while taking this medication. This medication can interact with other hypoglycemic agents or several medications; therefore, if you are taking other medications, you must inform your healthcare provider. Pregnant or breastfeeding women are advised to avoid using this medication, and insulin treatment is a safer alternative during pregnancy. Elderly patients are at risk for impaired renal function; therefore, dose adjustment and regular monitoring are necessary. In cases of overdose, treatments like blood dialysis may be needed, so you should visit a medical institution immediately. This medication should be swallowed whole without chewing or crushing; it is normal for the tablet shell to be expelled in feces.

Serious side effects

Lactic acidosis, severe allergic reactions (urticaria, severe swelling), difficulty breathing, liver abnormalities (jaundice), hypoglycemia, renal function deterioration, and severe edema.

Mild side effects

• Altered taste
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• erythema
• itching
• urticaria
• rash

This medication should be stored in a tightly closed container to protect it from air and moisture. Additionally, it is important to store it in a cool place below 25 degrees Celsius to maintain its efficacy.

Appearance

White to yellowish rectangular tablet

Package unit

30 tablets/bottle